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	Influence of triphenyltin exposure on the hypothalamus-pituitary-gonad axis in male Sebastiscus marmoratus
	Sun, Lingbin ; Zhang, Jiliang（Henan Univ Sci） ; Zuo, Zhenghong ; Zuo ZH(左正宏) ; Chen, Yixin ; Wang, Xinhong ; Huang, Xin ; Wang, Chonggang ; Wang ZG(王重刚)
	2011-05-07
关键词	Triphenyltin Testicular development Sebastiscus marmoratus Hypothalamus-pituitary-gonad axis
英文摘要	Both triphenyltin (TPT) and tributyltin (TBT) have been used as ingredients of antifouling biocides. However, far fewer studies addressing the reproductive toxicity of TPT on fishes are available than for TBT. The present study was conducted to investigate the effects of TPT at environmentally relevant concentrations on testicular development in male rockfish Sebastiscus marmoratus and to gain insight into its mechanism of action. After exposure for 48 days, the gonadosomatic index had decreased, and there was a reduced number of mature sperm and an abundance of the late stages of spermatocysts in the testes. Although the testosterone levels in the testes were elevated and the 17 beta-estradiol levels were decreased, spermatogenesis was suppressed. The activity of gamma-glutamyl transpeptidase (which is used as a Sertoli cell marker) was decreased after TPT exposure, and serious interstitial fibrosis was observed in the interlobular septa of the testes exposed to TPT. The increased expression of cGnRH-II (chicken-II type gonadotropin-releasing hormone) and sGnRH (salmon-type GnRH), and the decreased expression of LH beta (luteinizing hormone) in the fish brains were detected. The expression of FSH beta (follicle-stimulating hormone) was decreased at day 21, while was increased slightly at day 48. The changes of cGnRH-II, sGnRH. FSH beta and LH beta mRNA levels might have mainly resulted from the alteration of the sex steroids via feedback mechanisms. The decrease of the FSH beta mRNA might have been one of the reasons causing the dysfunction of Sertoli cells, which play a critical role during spermatogenesis. The results suggested that TPT could perturb the function of hypothalamus-pituitary-gonad axis, and inhibiting the spermatogenesis. (C) 2011 Elsevier B.V. All rights reserved.; National Natural Science Foundation of China[20777061]; program for Changjiang Scholars and Innovative Research Team in University[IRT0941]
语种	英语
出版者	ELSEVIER SCIENCE BV
内容类型	期刊论文
源URL	[http://dx.doi.org/doi:10.1016/j.aquatox.2011.04.018]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Sun, Lingbin,Zhang, Jiliang,Zuo, Zhenghong,et al. Influence of triphenyltin exposure on the hypothalamus-pituitary-gonad axis in male Sebastiscus marmoratus[J],2011.
APA	Sun, Lingbin.,Zhang, Jiliang.,Zuo, Zhenghong.,左正宏.,Chen, Yixin.,...&王重刚.(2011).Influence of triphenyltin exposure on the hypothalamus-pituitary-gonad axis in male Sebastiscus marmoratus..
MLA	Sun, Lingbin,et al."Influence of triphenyltin exposure on the hypothalamus-pituitary-gonad axis in male Sebastiscus marmoratus".(2011).

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