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	Tributyltin chloride results in dorsal curvature in embryo development of Sebastiscus marmoratus via apoptosis pathway
	Zhang, Jiliang ; Zuo, Zhenghong ; Zuo ZH(左正宏) ; Wang, Yuqing ; Yu, Ang ; Chen, Yixin ; Chen YX(陈亦欣) ; Wang, chonggang ; Wang ZG(王重刚)
	2010-10-20
关键词	Tributyltin Development Apoptosis Retinoid X receptor Sebastiscus marmoratus Embryo
英文摘要	Tributyltin (TBT) is a ubiquitous marine environmental contaminant characterized primarily by its reproductive toxicity. However, the embryotoxicity of TBT has not been extensively described, especially in fishes. The aim of this study was to investigate the developmental toxicity of waterborne TBT at environmental levels (0, 0.1, 1, and long L(-1) as Sn) on Sebastiscus marmoratus embryos. Our study showed that TBT reduced the hatchability and caused apparent morphological abnormalities including dorsal curvature, severely twisted tails and pericardial edema. In addition, localized apoptosis was found in the tail regions of embryos after TBT exposure. The study provided a possible mechanistic link between apoptosis and TBT-induced twisted tails abnormality. TBT exposure induced retinoid X receptor cc expression in S. marmoratus embryos at the 0.1 and 1 ng L(-1) group, which would be responsible for the increasing apoptotic cells induced by TBT. The results of the present study have widespread implications for environmental ecological assessment, management and the etiology of developmental defects. (C) 2010 Elsevier Ltd. All rights reserved.; National Natural Science Foundation of China[20977071]; Natural Scientific Fund in Fujian Province, China[2009J01225]
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
内容类型	期刊论文
源URL	[http://dx.doi.org/doi:10.1016/j.chemosphere.2010.09.057]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Zhang, Jiliang,Zuo, Zhenghong,Zuo ZH,et al. Tributyltin chloride results in dorsal curvature in embryo development of Sebastiscus marmoratus via apoptosis pathway[J],2010.
APA	Zhang, Jiliang.,Zuo, Zhenghong.,左正宏.,Wang, Yuqing.,Yu, Ang.,...&王重刚.(2010).Tributyltin chloride results in dorsal curvature in embryo development of Sebastiscus marmoratus via apoptosis pathway..
MLA	Zhang, Jiliang,et al."Tributyltin chloride results in dorsal curvature in embryo development of Sebastiscus marmoratus via apoptosis pathway".(2010).

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