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	Cdk5-Mediated Phosphorylation of Axin Directs Axon Formation during Cerebral Cortex Development
	Ip, Nancy Y. ; Fu, Amy K. Y. ; Chen, Yu ; Fang, Wei-Qun ; Ip, Jacque P. K. ; Li, Rui ; Ng, Yu Pong ; Lin, Sheng-Cai ; Lin SC(林圣彩)
	2011-07-25
英文摘要	Axon formation is critical for the establishment of connections between neurons, which is a prerequisite for the development of neural circuitry. Kinases such as cyclin-dependent kinase 5 (Cdk5) and glycogen synthase kinase-3 beta (GSK-3 beta), have been implicated to regulate axon outgrowth. Nonetheless, the in vivo roles of these kinases in axon development and the underlying signaling mechanisms remain essentially unknown. We report here that Cdk5 is important for axon formation in mouse cerebral cortex through regulating the functions of axis inhibitor (Axin), a scaffold protein of the canonical Wnt pathway. Knockdown of Axin in utero abolishes the formation and projection of axons. Importantly, Axin is phosphorylated by Cdk5, and this phosphorylation facilitates the interaction of Axin with GSK-3 beta, resulting in inhibition of GSK-3 beta activity and dephosphorylation of its substrate collapsin response mediator protein-2 (CRMP-2), a microtubule-associated protein. Specifically, both phosphorylation of Axin and its interaction with GSK-3 beta are critically required for axon formation in mouse cortex development. Together, our findings reveal a new regulatory mechanism of axon formation through Cdk5-dependent phosphorylation of Axin.; Research Grants Council of Hong Kong (The Hong Kong University of Science and Technology)[661007, 660808, 661109, 660110, 1/06C]; University Grants Committee[AoE/B-15/01]; Hong Kong Jockey Club; Croucher Foundation
语种	英语
出版者	SOC NEUROSCIENCE
内容类型	期刊论文
源URL	[http://dx.doi.org/doi:10.1523/JNEUROSCI.3120-11.2011]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Ip, Nancy Y.,Fu, Amy K. Y.,Chen, Yu,et al. Cdk5-Mediated Phosphorylation of Axin Directs Axon Formation during Cerebral Cortex Development[J],2011.
APA	Ip, Nancy Y..,Fu, Amy K. Y..,Chen, Yu.,Fang, Wei-Qun.,Ip, Jacque P. K..,...&林圣彩.(2011).Cdk5-Mediated Phosphorylation of Axin Directs Axon Formation during Cerebral Cortex Development..
MLA	Ip, Nancy Y.,et al."Cdk5-Mediated Phosphorylation of Axin Directs Axon Formation during Cerebral Cortex Development".(2011).

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