Chronic Exposure to Phenanthrene Influences the Spermatogenesis of Male Sebastiscus marmoratus: U-Shaped Effects and the Reason for Them | |
Sun, Lingbin ; Zuo, Zhenghong ; Luo, Hongmin ; Chen, Meng ; Zhong, Yuanfu ; Chen, Yixin ; Chen YX(陈奕欣) ; Wang, Chonggan ; Wang ZG(王重刚) | |
2011-11-07 | |
英文摘要 | Phenanthrene (PHE) is one of the most abundant polycyclic aromatic hydrocarbons in the aquatic environment. This study was conducted to investigate the effects of PHE at environmentally relevant concentrations on testicular development in male Sebastiscus marmoratus. After SO days exposure, the gonadosomatic indices and percentage of sperm produced showed a U-shaped dose response. The levels of salmon-type gonadotropin releasing hormone, follicle-stimulating hormone, luteinizing hormone mRNA, 17 beta-estradiol, and gamma-glutamyl transpeptidase activity all showed a U-shaped dose response, which dearly demonstrated the U-shaped effects of PHE exposure on spermatogenesis and also elucidated the action pathway. This result would bring a difficulty and a challenge to any risk assessment of PHE exposure to the reproductive health of fishes. Thus far, there has been no ready explanation for a U-shaped dose-response curve, which is well recognized as a hormetic phenomenon for many hormones, drugs, and toxic compounds. In the present study, PHE accumulation in the brain showed an inverse U-shaped increase compared to the control. Glutathione S-transferase activity in the brain showed a U-shaped dose-response, which was related with the PHE accumulation. These results have given a reasonable explanation for the U-shaped dose-response via alteration of biotransformation enzyme activity in the brain.; National Natural Science Foundation of China[40476049]; Natural Scientific Fund of Fujian Province, China[2009J01225]; Program for Changjiang Scholars and Innovative Research Team in University[IRT0941] |
语种 | 英语 |
出版者 | AMER CHEMICAL SOC |
内容类型 | 期刊论文 |
源URL | [http://dx.doi.org/doi:10.1021/es202684w] ![]() |
专题 | 生命科学-已发表论文 |
推荐引用方式 GB/T 7714 | Sun, Lingbin,Zuo, Zhenghong,Luo, Hongmin,et al. Chronic Exposure to Phenanthrene Influences the Spermatogenesis of Male Sebastiscus marmoratus: U-Shaped Effects and the Reason for Them[J],2011. |
APA | Sun, Lingbin.,Zuo, Zhenghong.,Luo, Hongmin.,Chen, Meng.,Zhong, Yuanfu.,...&王重刚.(2011).Chronic Exposure to Phenanthrene Influences the Spermatogenesis of Male Sebastiscus marmoratus: U-Shaped Effects and the Reason for Them.. |
MLA | Sun, Lingbin,et al."Chronic Exposure to Phenanthrene Influences the Spermatogenesis of Male Sebastiscus marmoratus: U-Shaped Effects and the Reason for Them".(2011). |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论