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	Ubiquitination in Rho Signaling
	Ding, Feng ; Ding F(丁凤) ; Wang, Hong-Rui ; Yin, Zhenyu
	2011-10-11
关键词	Rho GTPase Ubiquitination E3 ubiquitin ligase
英文摘要	The Rho family small GTPases of the Ras superfamily play key roles in regulating diverse signaling pathways that control a myriad of fundamental cellular processes such as cytoskeletal dynamics, cell cycle progression, gene expression, cell polarity, migration and cell transformation. The Rho GTPases cycle between an active GTP-bound and an inactive GDP-bound form, which is controlled by many regulators including GEFs, GAPs and GDIs. Recent studies have revealed a new layer of regulation for Rho GTPases, indicating that several members of the Rho family of small GTPases including RhoA, Rac1, and RhoBTB, as well as the Ras family member Rap1B, are also regulated by the ubiquitin-proteasome pathway, which plays important roles in controlling cell polarity, migration, cell transformation and actin dynamics. Importantly, regulators for Rho GTP-GDP cycling such as RhoGDI and Rho-GEF ECT2 were also found to be modulated by the ubiquitin pathway. In this review, we focus on how ubiquitin signaling guides the fate and function of Rho GTPases and their regulators, especially how the E3 ubiquitin ligase Smurf1 regulates cell polarity and motility through targeting RhoA for ubiquitination and degradation.; National Natural Science Foundation of China[30970614, 31070771]; Fundamental Research Funds for the Central Universities[2010121087]; Specialized Research Fund for the Doctoral Program of Higher Education of China[20090121120017]; Project 111; State Bureau of Foreign Experts; Ministry of Education[B06016]; Science Planning Program of Fujian Province[2009J1010]; Nature Science Foundation of Fujian Province[2010J01231]
语种	英语
出版者	BENTHAM SCIENCE PUBL LTD
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/11595]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Ding, Feng,Ding F,Wang, Hong-Rui,et al. Ubiquitination in Rho Signaling[J],2011.
APA	Ding, Feng,丁凤,Wang, Hong-Rui,&Yin, Zhenyu.(2011).Ubiquitination in Rho Signaling..
MLA	Ding, Feng,et al."Ubiquitination in Rho Signaling".(2011).

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