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	Frequency and distribution of AP-1 sites in the human genome
	Zhou, Huamin ; Zhou HM(周化民) ; Zarubin, Tyler ; Ji, Zhiliang ; Ji ZL(纪志梁) ; Min, Zheng ; Zhu, Wei ; Downey, Jocelyn S. ; Lin, Shengcai ; Lin SC(林圣彩) ; Han, Jiahuai ; Han JH(韩家淮)
	2005
关键词	AP-1 promoter/enhancer element human genome frequency distribution
英文摘要	The AP-1-binding sequences are promoter/enhancer elements that play an essential role in the induction of many genes in mammalian cells; however, the number of genes containing AP-1 sites remains unknown. In order to better address the overall effect of AP-1 on expression of genes encoded by the entire genome, a genome-wide analysis of the frequency and distribution of AP-1 sites would be useful; yet to date, no such analysis of AP-1 sites or any other promoter/enhancer elements has been performed. We present here our study of the consensus AP-1 site and two single-bp variants showing that the frequency of AP-1 sites in promoter regions is significantly lower than their average rate of occurrence in the whole genomic sequence, as well as the frequency of a random heptanucleotide suggesting that nature has selected for a decrease in the frequency of AP-1 sites in the regulatory regions of genes. In addition, genes containing multiple AP-1 sites are more prevalent than those containing only one copy of an AP-1 site, which again may have evolved to allow for greater signal amplification or integration in the regulation of AP-1 target genes. However, the number of AP-1-regulated genes identified in various studies is far smaller than the number of genes containing potential AP-1 sites, indicating that not all AP-1 sites are activated in a given cell under a given condition, and is consistent with the prediction by others that cellular context determines which AP-1 sites are targeted by AP-1.
语种	英语
出版者	OXFORD UNIV PRESS
内容类型	期刊论文
源URL	[http://dx.doi.org/doi:10.1093/dnares/12.2.139]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Zhou, Huamin,Zhou HM,Zarubin, Tyler,et al. Frequency and distribution of AP-1 sites in the human genome[J],2005.
APA	Zhou, Huamin.,周化民.,Zarubin, Tyler.,Ji, Zhiliang.,纪志梁.,...&韩家淮.(2005).Frequency and distribution of AP-1 sites in the human genome..
MLA	Zhou, Huamin,et al."Frequency and distribution of AP-1 sites in the human genome".(2005).

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