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	Differential expression and regulation of prostaglandin transporter and metabolic enzymes in mouse uterus during blastocyst implantation
	Gao, Fei ; Lei, Wei ; Diao, Hong-Lu ; Hu, Shi-Jun ; Luan, Li-Ming ; Yang, Zeng-Ming ; Yang ZM(杨增明)
	2007
关键词	embryo implantation mouse uterus 15-PGDH CBR1 PGT
英文摘要	Objective: To examine the spatiotemporal expression and regulation of prostaglandin transporter (PGT), 15-hydroxy-PG dehydrogenase (15-PGDH), and carbonyl reductase 1 (CBR1) messenger RNA (mRNA) and protein in the mouse uterus during embryo implantation and in related models. Design: Experimental animal study. Setting: University research laboratory. Animal(s): Sexually mature female Kunming strain white mice. Intervention(s): Delayed and activated implantation, artificial decidualization, and subcutaneous injection of progesterone (P) and E-2 in ovariectomized mouse. Main Outcome Measure(s): The expression of mRNA and protein were detected by in situ hybridization and immunohistochemistry in mouse uterus. Result(s): Prostaglandin transporter mRNA and protein were expressed in the subluminal stroma at implantation site on day 5 of pregnancy and then in decidua but were not detected at the interimplantation sites and in preimplantation or pseudopregnant uterus. The presence of an active blastocyst was required for PGT expression at the implantation site. Both 15-PGDH and CBR1 mRNA were detected in glandular epithelium on day 4 of pregnancies. The expression of 15-PGDH and CBR1 mRNA was also detected in postimplantation embryos. Conclusion(s): These data suggest that differentially expressed PGT and 15-PGDH may participate in PG signaling in mouse uterus during implantation and decidualization.
语种	英语
出版者	ELSEVIER SCIENCE INC
内容类型	期刊论文
源URL	[http://dx.doi.org/doi:10.1016/j.fertnstert.2007.02.054]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Gao, Fei,Lei, Wei,Diao, Hong-Lu,et al. Differential expression and regulation of prostaglandin transporter and metabolic enzymes in mouse uterus during blastocyst implantation[J],2007.
APA	Gao, Fei.,Lei, Wei.,Diao, Hong-Lu.,Hu, Shi-Jun.,Luan, Li-Ming.,...&杨增明.(2007).Differential expression and regulation of prostaglandin transporter and metabolic enzymes in mouse uterus during blastocyst implantation..
MLA	Gao, Fei,et al."Differential expression and regulation of prostaglandin transporter and metabolic enzymes in mouse uterus during blastocyst implantation".(2007).

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