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	Interaction between importin 13 and myopodin suggests a nuclear import pathway for myopodin
	Liang, Jie ; Ke, Guifen ; You, Wenjun（ No 1 Hosp Xiamen） ; Peng, Zi ; Lan, Jie（McGill Univ, Montreal Childrens Hosp） ; Kalesse, Markus（Leibniz Univ Hannover, Inst Organ Chem） ; Tartakoff, Alan M.（Case Western Reserve Univ, Dept Pathol, Cell Biol Program, Cleveland, OH USA） ; Kaplan, Feige（McGill Univ, Montreal Childrens Hosp） ; Tao, Tao ; Tao T(陶涛)
	2007
关键词	importin 13 myopodin interaction nuclear import
英文摘要	Importin 13 is a member of the importin beta superfamily of nuclear transport proteins and is expressed in multiple tissues at high levels both in humans and rodents, including fetal lung, brain, and heart. In order to elucidate potential functions of imp13 in the heart, we have used rat imp13 as bait to screen a human heart cDNA library and identified an interaction with the C-terminal peptide of myopodin (a.a. 360-698), an actin-bundling protein, associated with tumor-suppressor activity that localizes to both the cytoplasm and the nucleus. We have used GST-pull down assays and co-immunoprecipitation experiments to demonstrate an interaction between imp13 and full-length myopodin and observed that RanGTP dissociates the myopodin-imp13 complex. In studies of cultured cells, we show that both imp13 siRNA and a C-terminal fragment of imp13 protein prevent nuclear localization of myopodin. We, therefore, conclude that imp13 functions in myopodin import and we suggest that the regulation of these events is critical for normal and abnormal cellular differentiation.
语种	英语
出版者	SPRINGER
内容类型	期刊论文
源URL	[http://dx.doi.org/doi:10.1007/s11010-007-9588-1]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Liang, Jie,Ke, Guifen,You, Wenjun,et al. Interaction between importin 13 and myopodin suggests a nuclear import pathway for myopodin[J],2007.
APA	Liang, Jie.,Ke, Guifen.,You, Wenjun.,Peng, Zi.,Lan, Jie.,...&陶涛.(2007).Interaction between importin 13 and myopodin suggests a nuclear import pathway for myopodin..
MLA	Liang, Jie,et al."Interaction between importin 13 and myopodin suggests a nuclear import pathway for myopodin".(2007).

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