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	Expression and Hormonal Regulation of Hoxa10 in Canine Uterus During the Peri-implantation Period
	Guo, B. ; Zhang, X-M ; Yue, Z-P ; Tian, Z. ; Han, B-C ; Yang, Z-M ; Yang ZM(杨增明)
	2009
英文摘要	Hoxa10, a homeobox gene, is necessary for endometrial receptivity to blastocyst implantation. The aim of this study was to investigate the differential expression of Hoxa10 in canine uterus during early pregnancy and its regulation under different conditions by in situ hybridization. Hoxa10 mRNA was mainly localized in glandular epithelium and myometrium in canine uterus. There was a low level of Hoxa10 expression in the glandular epithelium on days 6, 12 and 17 of pregnancy. On day 20 of pregnancy when embryo implanted, Hoxa10 mRNA was highly expressed in the glandular epithelium surrounding the embryo, but not in the luminal epithelium. The expression of Hoxa10 mRNA gradually declined from day 23 and reached a low level on day 28. In the myometrium, a low level of Hoxa10 mRNA signal was seen on days 6, 12 and 17 of pregnancy and reached a high level on day 20 of pregnancy. During the estrous cycle, a high level of Hoxa10 mRNA expression was seen in the estrous uterus. Either estrogen or progesterone significantly induced the expression of Hoxa10 mRNA in the ovariectomized canine uterus. These results suggest that Hoxa10 expression is closely related to canine embryo implantation and upregulated by estrogen and progesterone.; National Basic Research Program of China [2006CB504005, 2006CB944009]; National Natural Science Foundation of China [30371032, 30571340]; National Hi-Tech Research Development Program of China [2007AA10Z150]
语种	英语
出版者	WILEY-BLACKWELL PUBLISHING, INC
内容类型	期刊论文
源URL	[http://dx.doi.org/doi:10.1111/j.1439-0531.2007.01037.x]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Guo, B.,Zhang, X-M,Yue, Z-P,et al. Expression and Hormonal Regulation of Hoxa10 in Canine Uterus During the Peri-implantation Period[J],2009.
APA	Guo, B..,Zhang, X-M.,Yue, Z-P.,Tian, Z..,Han, B-C.,...&杨增明.(2009).Expression and Hormonal Regulation of Hoxa10 in Canine Uterus During the Peri-implantation Period..
MLA	Guo, B.,et al."Expression and Hormonal Regulation of Hoxa10 in Canine Uterus During the Peri-implantation Period".(2009).

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