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	Role of Hypoxia in the Hallmarks of Human Cancer
	Ruan, Kai ; Song, Gang ; Song G(宋刚) ; Ouyang, Gaoliang ; 欧阳高亮
	2009
关键词	HYPOXIA HYPOXIA INDUCIBLE FACTOR CANCER MICROENVIRONMENT METASTASIS METABOLISM
英文摘要	Hypoxia has been recognized as one oft he fund a mentally important features of solid tumors and plays a critical role in various cellular and physiologic events, including cell proliferation, survival, angiogenesis, immunosurveillance, metabolism, as well as tumor invasion and metastasis. These responses to hypoxia are at least partially orchestrated by activation of the hypoxia-inducible factors (HIFs). HIF-1 is a key regulator of the response of mammalian cells to oxygen deprivation and plays critical roles in the adaptation of tumor cells to a hypoxic microenvironment. Hypoxia and overexpression of HIF-1 have been associated with radiation therapy and chemotherapy resistance, an increased risk of invasion and metastasis, and a poor clinical prognosis of solid tumors. The discovery of HIF-1 signaling has led to a rapidly increasing understanding of the complex mechanisms involved in tumor hypoxia and has helped greatly in screening novel anticancer agents. In this review, we will first introduce the cellular responses to hypoxia and HIF-1 signaling pathway in hypoxia, and then summarize the multifaceted role of hypoxia in the hallmarks of human cancers. J. Cell. Biochem. 107: 1053-1062, 2009. (C) 2009 Wiley-Liss, Inc.; National Natural Science Foundation of China [30400239, 30570935, 30871242]
语种	英语
出版者	WILEY-LISS
内容类型	期刊论文
源URL	[http://dx.doi.org/doi:10.1002/jcb.22214]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Ruan, Kai,Song, Gang,Song G,et al. Role of Hypoxia in the Hallmarks of Human Cancer[J],2009.
APA	Ruan, Kai,Song, Gang,宋刚,Ouyang, Gaoliang,&欧阳高亮.(2009).Role of Hypoxia in the Hallmarks of Human Cancer..
MLA	Ruan, Kai,et al."Role of Hypoxia in the Hallmarks of Human Cancer".(2009).

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