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	Expression and Hormonal Regulation of IL-11R alpha in Canine Uterus During Early Pregnancy
	Guo, B. ; Yue, Z-P ; Han, B-C ; Tian, Z ; Yang, Z-M ; Yang ZM(杨增明) ; Zhao, T-Y ; Zeng, L.
	2009
英文摘要	Contents Embryo implantation is critical for the successful establishment of pregnancy. Interleukin-11 (IL-11) is essential for adequate decidualization in the mouse and human via binding to the specific IL-11 receptor alpha (IL-11R alpha). But the expression and regulation of IL-11 and IL-11R alpha in the canine endometrium remain unknown. The aim of this study was to investigate the differential expression of IL-11R alpha in canine uterus during early pregnancy and its regulation under different conditions by in situ hybridization. Interleukin-11R alpha mRNA was mainly localized in glandular epithelium in canine uterus. There was a low level of IL-11R alpha expression in the glandular epithelium on days 6, 12 and 17 of pregnancy. On day 20 of pregnancy when embryo implanted, IL-11R alpha mRNA was highly expressed in the glandular epithelium surrounding the embryo, but not in the luminal epithelium and stroma. On day 23 of pregnancy, the expression of IL-11R alpha mRNA maintained a constant level compared with the expression of day 20 and increased on day 28 of pregnancy. During the oestrous cycle, a high level of IL-11R alpha mRNA expression was seen in the oestrous uterus. Progesterone slightly induced the expression of IL-11R alpha mRNA in the ovariectomized canine uterus. These results suggest that IL-11R alpha expression is closely related to canine implantation and up-regulated by progesterone.; National Basic Research Program of China [2006CB504005, 2006CB944009]; National Natural Science Foundation of China [30371032, 30571340]; National Hi-Tech Research Development Program of China [2007AA10Z150]
语种	英语
出版者	WILEY-BLACKWELL PUBLISHING, INC
内容类型	期刊论文
源URL	[http://dx.doi.org/doi:10.1210/er.21.3.313]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Guo, B.,Yue, Z-P,Han, B-C,et al. Expression and Hormonal Regulation of IL-11R alpha in Canine Uterus During Early Pregnancy[J],2009.
APA	Guo, B..,Yue, Z-P.,Han, B-C.,Tian, Z.,Yang, Z-M.,...&Zeng, L..(2009).Expression and Hormonal Regulation of IL-11R alpha in Canine Uterus During Early Pregnancy..
MLA	Guo, B.,et al."Expression and Hormonal Regulation of IL-11R alpha in Canine Uterus During Early Pregnancy".(2009).

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