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	Polyamines are essential in embryo implantation: Expression and function of polyamine-related genes in mouse uterus during peri-implantation period
	Zhao, Yue-Chao ; Yang, Zeng-Ming ; Yang ZM(杨增明) ; Chi, Yu-Jing（NE Agr Univ） ; Yu, Yong-Sheng（NE Agr Univ） ; Liu, Ji-Long（NE Agr Univ） ; Su, Ren-Wei（NE Agr Univ） ; Ma, Xing-Hong（NE Agr Univ） ; Shan, Chun-Hua（NE Agr Univ）
	2008
英文摘要	Polyamines are key regulators in cell growth and differentiation. It has been shown that ornithine decarboxylase (Odc) was essential for post-implantation embryo development, and overexpression of spermidine/spermine N1-acetyltransferase will lead to ovarian hypofunction and hypoplastic uteri. However, the expression and function of polyamine-related genes in mouse uterus during early pregnancy are still unknown. In this study we investigated the expression, regulation, and function of polyamine-related genes in mouse uterus during the peri-implantation period. Odc expression was strongly detected at implantation sites and stimulated by estrogen treatment. The expression of Odc antizyme 1 and spermidine/spermine N1-acetyltransferase was also highly shown at implantation sites and regulated by Odc or polyamine level in uterine cells. Embryo implantation was significantly inhibited by alpha-difluoromethylornithine, an Odc inhibitor. Moreover, the reduction of Odc activity caused by alpha-difluoromethylornithine treatment was compensated by the up-regulation of S-adenosylmethionine decarboxylase gene expression. Collectively, our results indicated that the coordinated expression of uterine polyamine-related genes may be important for embryo implantation.
语种	英语
出版者	ENDOCRINE SOC
内容类型	期刊论文
源URL	[http://dx.doi.org/doi:10.1210/en.2007-1420]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Zhao, Yue-Chao,Yang, Zeng-Ming,Yang ZM,et al. Polyamines are essential in embryo implantation: Expression and function of polyamine-related genes in mouse uterus during peri-implantation period[J],2008.
APA	Zhao, Yue-Chao.,Yang, Zeng-Ming.,杨增明.,Chi, Yu-Jing.,Yu, Yong-Sheng.,...&Shan, Chun-Hua.(2008).Polyamines are essential in embryo implantation: Expression and function of polyamine-related genes in mouse uterus during peri-implantation period..
MLA	Zhao, Yue-Chao,et al."Polyamines are essential in embryo implantation: Expression and function of polyamine-related genes in mouse uterus during peri-implantation period".(2008).

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