Reduction of spermatogenesis in mice after tributyltin administration | |
Chen, Yufang ; Zuo, Zhenghong ; Zuo ZH(左正宏) ; Chen, Shuzhen ; Yan, Feihuang ; Chen, Yixin ; Chen YX(陈奕欣) ; Yang, Zengming ; Yang ZM(杨增明) ; Wang, Chonggang ; Wang ZG(王重刚) | |
2008 | |
关键词 | Tributyltin Spermatogenesis Estrogen receptor Mice |
英文摘要 | Organotin compounds, such as tributyltin (TBT) used as an antifouling biocide, can induce masculinization in female mollusks. However, few studies addressing the effect of TBT on spermatogenesis in mammalian have been reported. This study was conducted to investigate the effects of TBT at low doses (0.5, 5, and 50 mu g/kg, respectively) on spermatogenesis in mice as exposed from puberty and gave insight into the mechanism. After exposure for 30 days, the gonadosomatic index (GSI) was significantly decreased. The testosterone levels in the testes were not altered and the 17 beta-estradiol levels were significantly decreased in a dose-dependent manner, spermatogenesis of the testis was significantly inhibited. Estrogen receptor (ER-alpha and ER-beta) levels in testes of the mice exposed to TBT were decreased in a dose-dependent manner. The results suggest that ER play an important role in TBT-mediated inhibition of spermatogenesis. (C) 2008 Elsevier Ireland Ltd. All rights reserved.; National Basic Research Program of China [2006CB504005] |
语种 | 英语 |
出版者 | ELSEVIER IRELAND LTD |
内容类型 | 期刊论文 |
源URL | [http://dx.doi.org/doi:10.1016/j.tox.2008.06.015] ![]() |
专题 | 生命科学-已发表论文 |
推荐引用方式 GB/T 7714 | Chen, Yufang,Zuo, Zhenghong,Zuo ZH,et al. Reduction of spermatogenesis in mice after tributyltin administration[J],2008. |
APA | Chen, Yufang.,Zuo, Zhenghong.,左正宏.,Chen, Shuzhen.,Yan, Feihuang.,...&王重刚.(2008).Reduction of spermatogenesis in mice after tributyltin administration.. |
MLA | Chen, Yufang,et al."Reduction of spermatogenesis in mice after tributyltin administration".(2008). |
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