QQ客服 官方微博 反馈留言

	Reduction of spermatogenesis in mice after tributyltin administration
	Chen, Yufang ; Zuo, Zhenghong ; Zuo ZH(左正宏) ; Chen, Shuzhen ; Yan, Feihuang ; Chen, Yixin ; Chen YX(陈奕欣) ; Yang, Zengming ; Yang ZM(杨增明) ; Wang, Chonggang ; Wang ZG(王重刚)
	2008
关键词	Tributyltin Spermatogenesis Estrogen receptor Mice
英文摘要	Organotin compounds, such as tributyltin (TBT) used as an antifouling biocide, can induce masculinization in female mollusks. However, few studies addressing the effect of TBT on spermatogenesis in mammalian have been reported. This study was conducted to investigate the effects of TBT at low doses (0.5, 5, and 50 mu g/kg, respectively) on spermatogenesis in mice as exposed from puberty and gave insight into the mechanism. After exposure for 30 days, the gonadosomatic index (GSI) was significantly decreased. The testosterone levels in the testes were not altered and the 17 beta-estradiol levels were significantly decreased in a dose-dependent manner, spermatogenesis of the testis was significantly inhibited. Estrogen receptor (ER-alpha and ER-beta) levels in testes of the mice exposed to TBT were decreased in a dose-dependent manner. The results suggest that ER play an important role in TBT-mediated inhibition of spermatogenesis. (C) 2008 Elsevier Ireland Ltd. All rights reserved.; National Basic Research Program of China [2006CB504005]
语种	英语
出版者	ELSEVIER IRELAND LTD
内容类型	期刊论文
源URL	[http://dx.doi.org/doi:10.1016/j.tox.2008.06.015]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Chen, Yufang,Zuo, Zhenghong,Zuo ZH,et al. Reduction of spermatogenesis in mice after tributyltin administration[J],2008.
APA	Chen, Yufang.,Zuo, Zhenghong.,左正宏.,Chen, Shuzhen.,Yan, Feihuang.,...&王重刚.(2008).Reduction of spermatogenesis in mice after tributyltin administration..
MLA	Chen, Yufang,et al."Reduction of spermatogenesis in mice after tributyltin administration".(2008).

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。