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	Osteopontin Prevents Curcumin-Induced Apoptosis and Promotes Survival Through Akt Activation via alpha(v)beta(3) Integrins in Human Gastric Cancer Cells
	Mao, Yubin ; Song, Gang ; Ming, Yanlin ; Bao, Shiden ; Bao SD(鲍仕登) ; Ouyang, Gaoliang ; 欧阳高亮
	2008
关键词	osteopontin (OPN) curcumin apoptosis Akt gastric cancer
英文摘要	Osteopontin (OPN) is a secreted, integrin-binding matrix phosphorylated glycoprotein that is overexpressed in many advanced cancers. However, the functional mechanisms by which OPN contributes to gastric cancer development are poorly understood. Here, we report that curcumin inhibited the growth of SGC7901 cell and induced apoptosis in a concentration- and time-dependent manner, while the acquired expression of OPN in SGC7901 cells dramatically promoted cell survival under serum depletion and prevented curcumin-induced apoptosis. Furthermore, PI3-K inhibitor LY294002 attenuated OPN-mediated Akt activation. Moreover, inhibiting the binding of OPN to alpha(v)beta(3) integrins reduced activation of Akt. Taken together, these results demonstrate that the pro-survival and anti-apoptosis activities of OPN in gastric cancer cells are mediated in part through PI3-K/Akt pathway via alpha(v)beta(3) integrins. Exp Biol Med 233: 1537-1545, 2008; National Natural science Foundation of China [30370307, 30400239, 30570915]; Program for New Century Excellent Talents in Xiamen University
语种	英语
出版者	SOC EXPERIMENTAL BIOLOGY MEDICINE
内容类型	期刊论文
源URL	[http://dx.doi.org/doi:10.3181/0805-RM-164]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Mao, Yubin,Song, Gang,Ming, Yanlin,et al. Osteopontin Prevents Curcumin-Induced Apoptosis and Promotes Survival Through Akt Activation via alpha(v)beta(3) Integrins in Human Gastric Cancer Cells[J],2008.
APA	Mao, Yubin.,Song, Gang.,Ming, Yanlin.,Bao, Shiden.,鲍仕登.,...&欧阳高亮.(2008).Osteopontin Prevents Curcumin-Induced Apoptosis and Promotes Survival Through Akt Activation via alpha(v)beta(3) Integrins in Human Gastric Cancer Cells..
MLA	Mao, Yubin,et al."Osteopontin Prevents Curcumin-Induced Apoptosis and Promotes Survival Through Akt Activation via alpha(v)beta(3) Integrins in Human Gastric Cancer Cells".(2008).

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