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	Inflammatory signaling and cellular senescence
	Han, Jiahuai ; Han JH(韩家淮) ; Ren, Jian-Lin ; Pan, Jin-Shui ; Lu, Ya-Pi ; Sun, Peiqing（Scripps Res Inst）
	2009
关键词	Inflammation Senescence Cancer
英文摘要	Inflammation acts as a double-edged sword in the pathogenesis of cancer. Inflammatory responses play a key role in eliminating potentially cancerous cells; however, an inflammatory microenvironment also promotes the development of cancer. Proinflammatory cytokines, the key mediators of inflammation, also play a dual role in oncogenesis. While they can promote neoplastic progression, recent studies have revealed an unexpected function of the inflammatory pathways in inhibiting cancer development. These studies demonstrate that cells undergoing senescence, a cellular program serving as a barrier to cancer development, produce increased amount of inflammatory cytokines. These inflammatory cytokines play an essential role in the initiation and maintenance of cellular senescence, and are responsible for triggering an innate immune response that clears the senescent tumor cells in vivo. The purpose of the present review is to discuss the dual roles of the inflammatory cytokines produced by senescent cells in the pathogenesis of cancer, and the signaling pathway mediating their role in cellular senescence. (c) 2008 Elsevier Inc. All rights reserved.; National Basic Research Program of China [2009CB522200]
语种	英语
出版者	ELSEVIER SCIENCE INC
内容类型	期刊论文
源URL	[http://dx.doi.org/doi:10.1016/j.cellsig.2008.10.011]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Han, Jiahuai,Han JH,Ren, Jian-Lin,et al. Inflammatory signaling and cellular senescence[J],2009.
APA	Han, Jiahuai,韩家淮,Ren, Jian-Lin,Pan, Jin-Shui,Lu, Ya-Pi,&Sun, Peiqing.(2009).Inflammatory signaling and cellular senescence..
MLA	Han, Jiahuai,et al."Inflammatory signaling and cellular senescence".(2009).

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