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	The uterine expression of SEC63 gene is up-regulated at implantation sites in association with the decidualization during the early pregnancy in mice
	Sun, Zhao-gui（Shanghai Inst Planned Parenthood Res） ; Chen, Qiu-ju（Shanghai Inst Planned Parenthood Res） ; Li, Run-sheng（Shanghai Inst Planned Parenthood Res） ; Wang, Jian（Shanghai Inst Planned Parenthood Res） ; Su, Ren-wei ; Zhao, Yue-chao ; Yang, Zeng-ming ; Yang ZM(杨增明)
	2009
英文摘要	Background: Sec63 is a key component of the protein translocation machinery in the mammalian endoplasmic reticulum (ER), and involved in the post-translation processing of secretory proteins. The aim of this study was to determine the expression pattern of SEC63 gene in mouse uterus during the early pregnancy. Methods: Real-time quantitative PCR and Western blot analyses were used to evaluate the alteration in levels of uterine SEC63 gene expression during the peri-implantation period in mice. Further, both in situ hybridization and immunohistochemical analyses were performed to examine the spatial localization of SEC63 gene expression in mouse uterine tissues. The presence of Sec63 protein in human uterine tissue was also detected by immunohistochemical analysis. Statistical analysis was carried out using Tukey test. Results: Uterine SEC63 gene expression was up-regulated and predominantly localized in mouse decidual cells during days 5-8 of pregnancy. More interestingly, Sec63 protein was also detected in human decidua of 10-week pregnancy, whereas was not observed in human endometrial tissues both at proliferative and secretory phases of menstrual cycle. Conclusion: The pattern of SEC63 gene expression is consistent with a possible role for SEC63 in decidualization.; National Basic Research Programme [2006CB504005]; National Natural Science Foundation of China [30672247]
语种	英语
出版者	BIOMED CENTRAL LTD
内容类型	期刊论文
源URL	[http://dx.doi.org/doi:10.1186/1477-7827-7-12]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Sun, Zhao-gui,Chen, Qiu-ju,Li, Run-sheng,et al. The uterine expression of SEC63 gene is up-regulated at implantation sites in association with the decidualization during the early pregnancy in mice[J],2009.
APA	Sun, Zhao-gui.,Chen, Qiu-ju.,Li, Run-sheng.,Wang, Jian.,Su, Ren-wei.,...&杨增明.(2009).The uterine expression of SEC63 gene is up-regulated at implantation sites in association with the decidualization during the early pregnancy in mice..
MLA	Sun, Zhao-gui,et al."The uterine expression of SEC63 gene is up-regulated at implantation sites in association with the decidualization during the early pregnancy in mice".(2009).

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