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	ChIP-seq and Functional Analysis of the SOX2 Gene in Colorectal Cancers
	Xuefeng Fang ; Wei Yu ; Lisha Li ; Jiaofang Shao ; Na Zhao ; Qiyun Chen ; Zhiyun Ye ; Sheng-Cai Lin ; Lin SC(林圣彩) ; Shu Zheng ; Biaoyang Lin
	2010
关键词	FACTOR-I RECEPTOR PLURIPOTENT STEM-CELLS COLON-CANCER REGULATE TRANSCRIPTION BREAST-CANCER EXPRESSION GENOME CARCINOMA OVEREXPRESSION APOPTOSIS
英文摘要	SOX2 is anHMGbox containing transcription factor that has been implicated in various types of cancer, but its role in colorectal cancers (CRC) has not been studied. Here we show that SOX2 is overexpressed in CRC tissues compared with normal adjacent tissues using immunohistochemical staining and RT-PCR. We also observed an increased SOX2 expression in nucleus of colorectal cancer tissues (46%, 14/30 cases vs. 7%, 2/30 adjacent tissues). Furthermore, knockdown of SOX2 in SW620 colorectal cancer cells decreased their growth rates in vitro cell line, and in vivo in xenograft models. ChIP-Seq analysis of SOX2 revealed a consensus sequence of wwTGywTT. An integrated expression profiling and ChIP-seq analysis show that SOX2 is involved in the BMP signaling pathway, steroid metabolic process, histone modifications, and many receptor-mediated signaling pathways such as IGF1R and ITPR2 (Inositol 1,4,5-triphosphate receptor, type 2).; MOST, China
语种	英语
出版者	OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/6316]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Xuefeng Fang,Wei Yu,Lisha Li,et al. ChIP-seq and Functional Analysis of the SOX2 Gene in Colorectal Cancers[J],2010.
APA	Xuefeng Fang.,Wei Yu.,Lisha Li.,Jiaofang Shao.,Na Zhao.,...&Biaoyang Lin.(2010).ChIP-seq and Functional Analysis of the SOX2 Gene in Colorectal Cancers..
MLA	Xuefeng Fang,et al."ChIP-seq and Functional Analysis of the SOX2 Gene in Colorectal Cancers".(2010).

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