ChIP-seq and Functional Analysis of the SOX2 Gene in Colorectal Cancers | |
Xuefeng Fang ; Wei Yu ; Lisha Li ; Jiaofang Shao ; Na Zhao ; Qiyun Chen ; Zhiyun Ye ; Sheng-Cai Lin ; Lin SC(林圣彩) ; Shu Zheng ; Biaoyang Lin | |
2010 | |
关键词 | FACTOR-I RECEPTOR PLURIPOTENT STEM-CELLS COLON-CANCER REGULATE TRANSCRIPTION BREAST-CANCER EXPRESSION GENOME CARCINOMA OVEREXPRESSION APOPTOSIS |
英文摘要 | SOX2 is anHMGbox containing transcription factor that has been implicated in various types of cancer, but its role in colorectal cancers (CRC) has not been studied. Here we show that SOX2 is overexpressed in CRC tissues compared with normal adjacent tissues using immunohistochemical staining and RT-PCR. We also observed an increased SOX2 expression in nucleus of colorectal cancer tissues (46%, 14/30 cases vs. 7%, 2/30 adjacent tissues). Furthermore, knockdown of SOX2 in SW620 colorectal cancer cells decreased their growth rates in vitro cell line, and in vivo in xenograft models. ChIP-Seq analysis of SOX2 revealed a consensus sequence of wwTGywTT. An integrated expression profiling and ChIP-seq analysis show that SOX2 is involved in the BMP signaling pathway, steroid metabolic process, histone modifications, and many receptor-mediated signaling pathways such as IGF1R and ITPR2 (Inositol 1,4,5-triphosphate receptor, type 2).; MOST, China |
语种 | 英语 |
出版者 | OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY |
内容类型 | 期刊论文 |
源URL | [http://dspace.xmu.edu.cn/handle/2288/6316] ![]() |
专题 | 生命科学-已发表论文 |
推荐引用方式 GB/T 7714 | Xuefeng Fang,Wei Yu,Lisha Li,et al. ChIP-seq and Functional Analysis of the SOX2 Gene in Colorectal Cancers[J],2010. |
APA | Xuefeng Fang.,Wei Yu.,Lisha Li.,Jiaofang Shao.,Na Zhao.,...&Biaoyang Lin.(2010).ChIP-seq and Functional Analysis of the SOX2 Gene in Colorectal Cancers.. |
MLA | Xuefeng Fang,et al."ChIP-seq and Functional Analysis of the SOX2 Gene in Colorectal Cancers".(2010). |
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