Alterations of tumor-related genes do not exactly match the histopathological grade in gastric adenocarcinomas

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	Alterations of tumor-related genes do not exactly match the histopathological grade in gastric adenocarcinomas
	Liu, Guo-Yan ; Liu, Kun-Hong ; Zhang, Yong ; Wang, Yu-Zhi ; Wu, Xiao-Hong ; Lu, Yi-Zhuo ; Pan, Chao ; Yin, Ping ; Liao, Hong-Feng ; Su, Ji-Qin ; Ge, Qing ; Luo, Qi ; Xiong, Bin ; Liu KH(刘昆宏)
刊名	http://dx.doi.org/10.3748/wjg.v16.i9.1129
	2010-03-07
关键词	FEATURING CANCER SUPPRESSOR GENE P53 MUTATIONS GENOME CLASSIFICATION PROLIFERATION EXPRESSION AUTOPHAGY INVASION
英文摘要	Xiamen Health Bureau [3502z20089009]; Xiamen Science and Technology Bureau [3502Z20074023]; Youth Fund of Fujian Health Department [2008-1-52]; Fujian Province, China; AIM: To investigate the diverse characteristics of different pathological gradings of gastric adenocarcinoma (GA) using tumor-related genes. METHODS: GA tissues in different pathological gradings and normal tissues were subjected to tissue arrays. Expressions of 15 major tumor-related genes were detected by RNA in situ hybridization along with 3' terminal digoxin-labeled anti-sense single stranded oligonucleotide and locked nucleic acid modifying probe within the tissue array. The data obtained were processed by support vector machines by four different feature selection methods to discover the respective critical gene/gene subsets contributing to the GA activities of different pathological gradings. RESULTS: In comparison of poorly differentiated GA with normal tissues, tumor-related gene TP53 plays a key role, although other six tumor-related genes could also achieve the Area Under Curve (AUC) of the receiver operating characteristic independently by more than 80%. Comparing the well differentiated GA with normal tissues, we found that 11 tumor-related genes could independently obtain the AUC by more than 80%, but only the gene subsets, TP53, RB and PTEN, play a key role. Only the gene subsets, Bcl10, UVRAG, APC, Beclin1, NM23, PTEN and RB could distinguish between the poorly differentiated and well differentiated GA. None of a single gene could obtain a valid distinction. CONCLUSION: Different from the traditional point of view, the well differentiated cancer tissues have more alterations of important tumor-related genes than the poorly differentiated cancer tissues. (C) 2010 Baishideng, All rights reserved.
语种	英语
出版者	WORLD J GASTROENTERO
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/90347]
专题	软件学院－已发表论文
推荐引用方式 GB/T 7714	Liu, Guo-Yan,Liu, Kun-Hong,Zhang, Yong,et al. Alterations of tumor-related genes do not exactly match the histopathological grade in gastric adenocarcinomas[J]. http://dx.doi.org/10.3748/wjg.v16.i9.1129,2010.
APA	Liu, Guo-Yan.,Liu, Kun-Hong.,Zhang, Yong.,Wang, Yu-Zhi.,Wu, Xiao-Hong.,...&刘昆宏.(2010).Alterations of tumor-related genes do not exactly match the histopathological grade in gastric adenocarcinomas.http://dx.doi.org/10.3748/wjg.v16.i9.1129.
MLA	Liu, Guo-Yan,et al."Alterations of tumor-related genes do not exactly match the histopathological grade in gastric adenocarcinomas".http://dx.doi.org/10.3748/wjg.v16.i9.1129 (2010).