A Novel Role of Dma1 in Regulating Forespore Membrane Assembly and Sporulation in Fission Yeast

CORC > 厦门大学 > 经济学院－已发表论文

	A Novel Role of Dma1 in Regulating Forespore Membrane Assembly and Sporulation in Fission Yeast
	Li, Wen-zhu ; Yu, Zhi-yong ; Ma, Peng-fei ; Wang, Yamei ; Jin, Quan-wen ; Wang YM(王艺明)
刊名	http://dx.doi.org/10.1091/mbc.E10-01-0079
	2010-12-15
关键词	SPINDLE POLE BODY INITIATION NETWORK SIN SCHIZOSACCHAROMYCES-POMBE MEIOSIS COILED-COIL PROTEIN NUCLEAR DIVISION SPORE FORMATION ASCOSPORE WALL MITOTIC EXIT GENE CYTOKINESIS
英文摘要	National Natural Science Foundation of China [30771078, 30871376]; Chinese Ministry of Education [108076]; Natural Science Foundation of Fujian Province of China [2007F3098]; Science Planning Program of Fujian Province [2009J1010]; 111 Project [B06016]; In fission yeast Schizosaccharomyces pombe, a diploid mother cell differentiates into an ascus containing four haploid ascospores following meiotic nuclear divisions, through a process called sporulation. Several meiosis-specific proteins of fission yeast have been identified to play essential roles in meiotic progression and sporulation. We report here an unexpected function of mitotic spindle checkpoint protein Dma1 in proper spore formation. Consistent with its function in sporulation, expression of dma1(+) is up-regulated during meiosis I and II. We showed that Dma1 localizes to the SPB during meiosis and the maintenance of this localization at meiosis II depends on septation initiation network (SIN) scaffold proteins Sid4 and Cdc11. Cells lacking Dma1 display defects associated with sporulation but not nuclear division, leading frequently to formation of asci with fewer spores. Our genetic analyses support the notion that Dma1 functions in parallel with the meiosis-specific Sid2-related protein kinase Slk1/Mug27 and the SIN signaling during sporulation, possibly through regulating proper forespore membrane assembly. Our studies therefore revealed a novel function of Dma1 in regulating sporulation in fission yeast.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/64892]
专题	经济学院－已发表论文
推荐引用方式 GB/T 7714	Li, Wen-zhu,Yu, Zhi-yong,Ma, Peng-fei,et al. A Novel Role of Dma1 in Regulating Forespore Membrane Assembly and Sporulation in Fission Yeast[J]. http://dx.doi.org/10.1091/mbc.E10-01-0079,2010.
APA	Li, Wen-zhu,Yu, Zhi-yong,Ma, Peng-fei,Wang, Yamei,Jin, Quan-wen,&王艺明.(2010).A Novel Role of Dma1 in Regulating Forespore Membrane Assembly and Sporulation in Fission Yeast.http://dx.doi.org/10.1091/mbc.E10-01-0079.
MLA	Li, Wen-zhu,et al."A Novel Role of Dma1 in Regulating Forespore Membrane Assembly and Sporulation in Fission Yeast".http://dx.doi.org/10.1091/mbc.E10-01-0079 (2010).