| 乳化-溶剂挥发法制备聚乳酸载药微球; Make microspheres through emulsion-solvent evaporation method | |
| 邵文尧 ; 何彩云 ; 冯艳玲 ; 陈玉清 | |
| 2015-01-05 | |
| 关键词 | 载药微球 o/w乳化-溶剂挥发法 聚乳酸 维A酸 包封率 microspheres emulsion-solvent evaporation vitamin A encapsulation efficiency |
| 英文摘要 | 采用O/W型乳化-溶剂挥发法来制备载药微球,以二氯甲烷为溶剂相,以聚乳酸为载体材料,以维A酸为包埋药物,以吐温-80和明胶为乳化剂。探索载药微球制备过程中的变量(高剪切转速、高剪切时间、内外相体积比、壁材用量等)对载药微球粒径大小、包封率以及稳定性等的影响。得出最优载药微球制备方案:明胶浓度7.5Mg/Ml,吐温浓度6Mg/Ml,聚乳酸浓度10 Mg/Ml,内外相体积比1∶10,剪切时间30MIn,搅拌速度300r/MIn,挥发时间3H。所制得的聚乳酸载药微球形态光滑且分散性较好,包封率为52.42%。; In this study,o/w emulsion-solvent evaporation method was used to make microspheres,using dichloromethane as the solvent phase,polylactic acid as the carrier material and vitamin A acid as the entrapped object,tween 80 and gelatine as emulsifier.The technical conditions such as shear speed,shear time,internal,external phase volume ratio and the amount of wall material were determined.The experiments demonstrated that the optimal conditions were:gelatin concentration of 7.5mg/mL,tween concentration of 6mg/mL,polylactic acid concentration of 10mg/mL,inside and outside the phase volume ratio of 1∶10,shearing time of 30 min,stirring speed of 300r/min,volatile time of 3h.The final product was smooth and well dispersed,and the encapsulation efficiency was 52.42%.; 国家自然科学基金资助项目(21406185); 福建省科技计划重点资助项目(2013H0043) |
| 语种 | zh_CN |
| 内容类型 | 期刊论文 |
| 源URL | [http://dspace.xmu.edu.cn/handle/2288/107215]  |
| 专题 | 化学化工－已发表论文 |
| 推荐引用方式 GB/T 7714 | 邵文尧,何彩云,冯艳玲,等. 乳化-溶剂挥发法制备聚乳酸载药微球, Make microspheres through emulsion-solvent evaporation method[J],2015. |
| APA | 邵文尧,何彩云,冯艳玲,&陈玉清.(2015).乳化-溶剂挥发法制备聚乳酸载药微球.. |
| MLA | 邵文尧,et al."乳化-溶剂挥发法制备聚乳酸载药微球".(2015). |
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