Design considerations of iron-based nanoclusters for noninvasive tracking of mesenchymal stem cell homing

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	Design considerations of iron-based nanoclusters for noninvasive tracking of mesenchymal stem cell homing
	Huang, Xinglu ; Zhang, ; Wang, Yu ; Sun, Xiaolian ; Choi, Ki Young ; Liu, Dingbin ; Choi, Jin-Sil ; Shin, Tae-Hyun ; Cheon, Jinwoo ; Niu, Gang ; Chen, Xiaoyuan ; Zhang F(张帆) ; Chen XY(陈小元)
刊名	http://dx.doi.org/10.1021/nn4062726
	2014
关键词	Brain Flowcharting Iron Magnetic resonance imaging Nanoclusters Stem cells
英文摘要	Stem-cell-based therapies have attracted considerable interest in regenerative medicine and oncological research. However, a major limitation of systemic delivery of stem cells is the low homing efficiency to the target site. Here, we report a serendipitous finding that various iron-based magnetic nanoparticles (MNPs) actively augment chemokine receptor CXCR4 expression of bone-marrow-derived mesenchymal stem cells (MSCs). On the basis of this observation, we designed an iron-based nanocluster that can effectively label MSCs, improve cell homing efficiency, and track the fate of the cells in vivo. Using this nanocluster, the labeled MSCs were accurately monitored by magnetic resonance imaging and improved the homing to both traumatic brain injury and glioblastoma models as compared to unlabeled MSCs. Our findings provide a simple and safe method for imaging and targeted delivery of stem cells and extend the potential applications of iron-based MNPs in regenerative medicine and oncology. ? 2014 American Chemical Society.
语种	英语
出版者	AMER CHEMICAL SOC
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/89771]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Huang, Xinglu,Zhang,,Wang, Yu,et al. Design considerations of iron-based nanoclusters for noninvasive tracking of mesenchymal stem cell homing[J]. http://dx.doi.org/10.1021/nn4062726,2014.
APA	Huang, Xinglu.,Zhang,.,Wang, Yu.,Sun, Xiaolian.,Choi, Ki Young.,...&陈小元.(2014).Design considerations of iron-based nanoclusters for noninvasive tracking of mesenchymal stem cell homing.http://dx.doi.org/10.1021/nn4062726.
MLA	Huang, Xinglu,et al."Design considerations of iron-based nanoclusters for noninvasive tracking of mesenchymal stem cell homing".http://dx.doi.org/10.1021/nn4062726 (2014).