Photo- and pH-triggered release of anticancer drugs from mesoporous silica-coated Pd@Ag nanoparticles

CORC > 厦门大学 > 化学化工－已发表论文

	Photo- and pH-triggered release of anticancer drugs from mesoporous silica-coated Pd@Ag nanoparticles
	Fang, Weijun ; Yang, Jing ; Gong, Jiawei ; Zheng, Nanfeng ; Yang J(杨静) ; Zheng NF(郑南峰)
刊名	http://dx.doi.org/10.1002/adfm.201101960
	2012-02-22
关键词	Cells Chemotherapy Coated materials Drug delivery Infrared devices Irradiation Loading Molecular biology Nanoparticles Shells (structures)
英文摘要	A smart drug delivery system integrating both photothermal therapy and chemotherapy for killing cancer cells is reported. The delivery system is based on a mesoporous silica-coated Pd@Ag nanoplates composite. The Pd@Ag nanoplate core can effectively absorb and convert near infrared (NIR) light into heat. The mesoporous silica shell is provided as the host for loading anticancer drug, doxorubicin (DOX). The mesoporous shell consists of large pores, 鈭?0 nm in diameter, and allows the DOX loading as high as 49% in weight. DOX loaded core-shell nanoparticles exhibit a higher efficiency in killing cancer cells than free DOX. More importantly, DOX molecules are loaded in the mesopores shell through coordination bonds that are responsive to pH and heat. The release of DOX from the core-shell delivery vehicles into cancer cells can be therefore triggered by the pH drop caused by endocytosis and also NIR irradiation. A synergistic effect of combining chemotherapy and photothermal therapy is observed in our core-shell drug delivery system. The cell-killing efficacy by DOX-loaded core-shell particles under NIR irradiation is higher than the sum of chemotherapy by DOX-loaded particles and photothermal therapy by core-shell particles without DOX. Based on mesoporous silica-coated Pd@Ag nanoparticles, a smart drug delivery system with anticancer drugs coordinated inside the mesopores is designed and developed. The release of the loaded anticancer drugs is triggered by pH and near infrared (NIR) light irradiation. Copyright 漏 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
语种	英语
出版者	Wiley-VCH Verlag
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/89523]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Fang, Weijun,Yang, Jing,Gong, Jiawei,et al. Photo- and pH-triggered release of anticancer drugs from mesoporous silica-coated Pd@Ag nanoparticles[J]. http://dx.doi.org/10.1002/adfm.201101960,2012.
APA	Fang, Weijun,Yang, Jing,Gong, Jiawei,Zheng, Nanfeng,杨静,&郑南峰.(2012).Photo- and pH-triggered release of anticancer drugs from mesoporous silica-coated Pd@Ag nanoparticles.http://dx.doi.org/10.1002/adfm.201101960.
MLA	Fang, Weijun,et al."Photo- and pH-triggered release of anticancer drugs from mesoporous silica-coated Pd@Ag nanoparticles".http://dx.doi.org/10.1002/adfm.201101960 (2012).