The four-step total synthesis of (-)-chaetominine | |
Peng, Qi-Long ; Luo, Shi-Peng ; Xia, Xiao-Er ; Liu, Liang-Xian ; Huang, Pei-Qiang ; Huang PQ(黄培强) | |
刊名 | http://dx.doi.org/10.1039/c3cc48833k
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2014 | |
关键词 | PROTECTING-GROUP-FREE DIPEPTIDE METHYL-ESTERS HIGH-YIELDING SYNTHESIS DIRECT TRANSFORMATION SECONDARY AMIDES NATURAL-PRODUCTS STEREOCHEMICAL ASSIGNMENT REDUCTIVE ALKYLATION STEP ECONOMY ACTIVATION |
英文摘要 | National Basic Research Program (973 Program) of China [2010CB833200]; NSF of China [21332007, 21072160]; Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT) of Ministry of Education, China; The total synthesis of the alkaloid (-)-chaetominine (1) has been achieved in four steps with an overall yield of 33.4%. Key features of our strategy include a one-pot cascade indole epoxidation - epoxide ring-opening cyclization - lactamization reaction sequence, and the use of a nitro group as a latent amino group for the one-pot construction of the quinazolinone ring. This constitutes a step economical, redox economical and protecting group-free total synthesis. |
语种 | 英语 |
出版者 | ROYAL SOC CHEMISTRY |
内容类型 | 期刊论文 |
源URL | [http://dspace.xmu.edu.cn/handle/2288/89479] ![]() |
专题 | 化学化工-已发表论文 |
推荐引用方式 GB/T 7714 | Peng, Qi-Long,Luo, Shi-Peng,Xia, Xiao-Er,et al. The four-step total synthesis of (-)-chaetominine[J]. http://dx.doi.org/10.1039/c3cc48833k,2014. |
APA | Peng, Qi-Long,Luo, Shi-Peng,Xia, Xiao-Er,Liu, Liang-Xian,Huang, Pei-Qiang,&黄培强.(2014).The four-step total synthesis of (-)-chaetominine.http://dx.doi.org/10.1039/c3cc48833k. |
MLA | Peng, Qi-Long,et al."The four-step total synthesis of (-)-chaetominine".http://dx.doi.org/10.1039/c3cc48833k (2014). |
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