Insulin and Insulin-Tripalmitin Particles Produced by a Supercritical Assisted Drying Process

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	Insulin and Insulin-Tripalmitin Particles Produced by a Supercritical Assisted Drying Process
	Hu, Xiaohui ; Jiang, Maoxing ; Wang, JingXian ; Zhu, Linjing ; Zheng, Shengxuan ; Snavely, William K. ; Hong, Yanzheng ; Su, Yuzhong ; Wang, Hongtao ; Li, Jun ; Li J(李军)
刊名	http://dx.doi.org/10.1080/07373937.2013.829852
	2013
关键词	Carbon dioxide Composite materials Drying Electromagnetic wave emission Ethanol Particle size analysis Supercritical fluid extraction Thermodynamic properties
英文摘要	A supercritical assisted drying (SAD) process was employed to produce insulin submicroparticles from an ethanol/water solution. The effect of the processing conditions on the morphology, size, and thermodynamic activity of the produced particles was investigated. Insulin particles generated from the process were generally spherical with average sizes between 0.4 and 1.1 μm. FTIR, HPLC, the Lowry method, and DTA-TG were implemented to investigate the thermodynamic activity and solvent residue of the produced particles. Results showed that the ethanol content of the aqueous solution had a more sensitive effect on the thermodynamic activity of the insulin particles than other operating factors; a high content of ethanol tended to denature the insulin particles. A rapid expansion of supercritical solutions (RESS)-SAD combined process was proposed to produce insulin-tripalmitin composite particles. Results indicated that irregular composite particles with insulin content of 33.1%, having a bimodal particle size distribution with two peaks at 3.5 and 11.0 μm, were obtained at 50.0°C and 12.0 MPa. These particles revealed no initial burst with a sustained release of insulin of more than 400 min. ? 2013 Copyright Taylor and Francis Group, LLC.
语种	英语
出版者	Taylor and Francis Inc.
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/89211]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Hu, Xiaohui,Jiang, Maoxing,Wang, JingXian,et al. Insulin and Insulin-Tripalmitin Particles Produced by a Supercritical Assisted Drying Process[J]. http://dx.doi.org/10.1080/07373937.2013.829852,2013.
APA	Hu, Xiaohui.,Jiang, Maoxing.,Wang, JingXian.,Zhu, Linjing.,Zheng, Shengxuan.,...&李军.(2013).Insulin and Insulin-Tripalmitin Particles Produced by a Supercritical Assisted Drying Process.http://dx.doi.org/10.1080/07373937.2013.829852.
MLA	Hu, Xiaohui,et al."Insulin and Insulin-Tripalmitin Particles Produced by a Supercritical Assisted Drying Process".http://dx.doi.org/10.1080/07373937.2013.829852 (2013).