Understanding the metabolic fate and assessing the biosafety of MnO nanoparticles by metabonomic analysis

CORC > 厦门大学 > 化学化工－已发表论文

	Understanding the metabolic fate and assessing the biosafety of MnO nanoparticles by metabonomic analysis
	Li, Jinquan ; Zhao, Zhenghuan ; Feng, Jianghua ; Gao, Jinhao ; Chen, Zhong ; Gao JH(高锦豪) ; Chen Z(陈忠)
刊名	http://dx.doi.org/10.1088/0957-4484/24/45/455102
	2013
关键词	MANGANESE TOXICITY STRESS TISSUE BRAIN RATS
英文摘要	National Natural Science Foundation of China [20605025, 81272581]; Fundamental Research Funds for the Central Universities [2011121046]; Recently, some types of MnO nanoparticle (Mn-NP) with favorable imaging capacity have been developed to improve the biocompatible profile of the existing Mn-based MRI contrast agent Mn-DPDP; however, the overall bio-effects and potential toxicity remain largely unknown. In this study, H-1 NMR-based metabolic profiling, integrated with traditional biochemical analysis and histopathological examinations, was used to investigate the absorption, distribution, metabolism, excretion and toxicity of Mn-NPs as candidates for MRI contrast agent. The metabolic responses in biofluids (plasma and urine) and tissues (liver, spleen, kidney, lung and brain) from rats could be divided into four classes following Mn-NP administration: Mn biodistribution-dependent, time-dependent, dose-dependent and complicated metabolic variations. The variations of these metabolites involved in lipid, energy, amino acid and other nutrient metabolism, which disclosed the metabolic fate and biological effects of Mn-NPs in rats. The changes of metabolic profile implied that the disturbance and impairment of biological functions induced by Mn-NP exposure were correlated with the particle size and the surface chemistry of nanoparticles. Integration of metabonomic technology with traditional methods provides a promising tool to understand the toxicological behavior of biomedical nanomaterials and will result in informed decision-making during drug development.
语种	英语
出版者	IOP PUBLISHING LTD
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/88788]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Li, Jinquan,Zhao, Zhenghuan,Feng, Jianghua,et al. Understanding the metabolic fate and assessing the biosafety of MnO nanoparticles by metabonomic analysis[J]. http://dx.doi.org/10.1088/0957-4484/24/45/455102,2013.
APA	Li, Jinquan.,Zhao, Zhenghuan.,Feng, Jianghua.,Gao, Jinhao.,Chen, Zhong.,...&陈忠.(2013).Understanding the metabolic fate and assessing the biosafety of MnO nanoparticles by metabonomic analysis.http://dx.doi.org/10.1088/0957-4484/24/45/455102.
MLA	Li, Jinquan,et al."Understanding the metabolic fate and assessing the biosafety of MnO nanoparticles by metabonomic analysis".http://dx.doi.org/10.1088/0957-4484/24/45/455102 (2013).