Exploring and exploiting the synergy of non-covalent interactions on the surface of gold nanoparticles for fluorescent turn-on sensing of bacterial lipopolysaccharide

CORC > 厦门大学 > 化学化工－已发表论文

	Exploring and exploiting the synergy of non-covalent interactions on the surface of gold nanoparticles for fluorescent turn-on sensing of bacterial lipopolysaccharide
	Gao, Jinhong ; Lai, Yangwei ; Wu, Chuanliu ; Zhao, Yibing ; Wu CL(吴川六) ; Zhao YB(赵一兵)
刊名	http://dx.doi.org/10.1039/c3nr02490c
	2013
关键词	COLORIMETRIC DETECTION ROOM-TEMPERATURE AQUEOUS-SOLUTION CANCER-CELLS RECOGNITION ENDOTOXIN SENSORS IDENTIFICATION MERCURY(II) MECHANISMS
英文摘要	National Natural Science Foundation of China [21075101]; National Basic Research Program of China [2011CB910403]; Planned Science and Technology Project of Xiamen, China [3502z20113006]; Specialized Research Fund for the Doctoral Program of Higher Education of China [200803840007]; NFFTBS [J1030415]; The sensing of lipopolysaccharide (LPS) relies on the synergy of multiple electrostatic and hydrophobic interactions between LPS and the sensor. However, how non-covalent interactions are coordinated to impel the recognition process still remains elusive, and the exploration of which would promote the development of LPS sensors with higher specificity and sensitivity. In this work, we hypothesize that Au NPs would provide a straightforward and flexible platform for studying the synergy of non-covalent interactions. The detailed mechanism of interactions between the designed fluorescent probes and Au NPs with two distinct surface properties was systematically explored. We demonstrated that only when the electrostatic attraction and hydrophobic stacking are both present, the binding of fluorescent probes onto Au NPs can be not only highly efficient, but also positively cooperative. After that, hybrid systems that consist of Au NPs and surface-assembled fluorescent probes were exploited for fluorescent turn-on sensing of LPS. The results show that the sensitivity and selectivity to LPS relies strongly on the binding affinity between fluorescent probes and Au NPs. Fluorescent probes assembled Au NPs thus provide an attractive platform for further optimization of the sensitivity/selectivity of LPS sensing.
语种	英语
出版者	ROYAL SOC CHEMISTRY
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/88734]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Gao, Jinhong,Lai, Yangwei,Wu, Chuanliu,et al. Exploring and exploiting the synergy of non-covalent interactions on the surface of gold nanoparticles for fluorescent turn-on sensing of bacterial lipopolysaccharide[J]. http://dx.doi.org/10.1039/c3nr02490c,2013.
APA	Gao, Jinhong,Lai, Yangwei,Wu, Chuanliu,Zhao, Yibing,吴川六,&赵一兵.(2013).Exploring and exploiting the synergy of non-covalent interactions on the surface of gold nanoparticles for fluorescent turn-on sensing of bacterial lipopolysaccharide.http://dx.doi.org/10.1039/c3nr02490c.
MLA	Gao, Jinhong,et al."Exploring and exploiting the synergy of non-covalent interactions on the surface of gold nanoparticles for fluorescent turn-on sensing of bacterial lipopolysaccharide".http://dx.doi.org/10.1039/c3nr02490c (2013).