Small Islets are Essential for Successful Intraportal Transplantation in a Diabetes Mouse Model

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	Small Islets are Essential for Successful Intraportal Transplantation in a Diabetes Mouse Model
	Su, Z. ; Xia, J. ; Shao, W. ; Cui, Y. ; Tai, S. ; Ekberg, H. ; Corbascio, M. ; Chen, J. ; Qi, Z. ; Shao W(邵巍) ; Qi Z(戚智)
刊名	http://dx.doi.org/10.1111/j.1365-3083.2010.02466.x
	2010-12
关键词	NITRIC-OXIDE GENERATION PANCREATIC-ISLETS INTERLEUKIN-1 LANGERHANS CELLS APOPTOSIS OUTCOMES FAILURE GRAFTS
英文摘要	joint research project of health and education, Fujian Province [WKJ2008-2-50]; Optimization of islet transplantation protocols is necessary for improved success of treatment for type 1 diabetes. Here, we investigated whether the size of islets transplanted into the portal vein (PV) of the liver can affect engraftment in the early post-transplantation in an experimental mouse model. Small (average diameter < 250 mu m, group A) or large (average diameter > 250 mu m, group B) islets (400 islet equivalents/recipient) purified from normal BALB/c mice were transplanted into syngenic recipients with diabetes induced by STZ. The percentage of mice returning to a non-diabetic status was higher in group A (100%) than that of group B (62.5%). Focal areas of liver necrosis associated with the islets emboli were observed in both groups, but the pathology in group B was significantly worse. Multiple proinflammatory cytokines were significantly higher in group B than that of A at 3 h post-transplantation. Our study determined that the size of islets plays a critical role in the success of intraportal islet transplantation (IPIT) and should be taken into account in future IPIT protocols for the treatment of diabetes.
语种	英语
出版者	SCAND J IMMUNOL
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/88428]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Su, Z.,Xia, J.,Shao, W.,et al. Small Islets are Essential for Successful Intraportal Transplantation in a Diabetes Mouse Model[J]. http://dx.doi.org/10.1111/j.1365-3083.2010.02466.x,2010.
APA	Su, Z..,Xia, J..,Shao, W..,Cui, Y..,Tai, S..,...&戚智.(2010).Small Islets are Essential for Successful Intraportal Transplantation in a Diabetes Mouse Model.http://dx.doi.org/10.1111/j.1365-3083.2010.02466.x.
MLA	Su, Z.,et al."Small Islets are Essential for Successful Intraportal Transplantation in a Diabetes Mouse Model".http://dx.doi.org/10.1111/j.1365-3083.2010.02466.x (2010).