ORGN 67-Flexible approaches for the asymmetric synthesis of bioactive alkaloids | |
Huang, PQ ; Huang PQ(黄培强) | |
2008-08-17 | |
英文摘要 | 2-Substituted 3-hetero-substituted pyrrolidines/ piperidines and tetramic acids are sub-structures found in a number of bioactive natural products, drugs and drug candidates. In this talk, we shall present our recent studies on the development of chiral non-racemic cyclic imides-based synthetic methodology and the complementary N-a-carbanion synthons-based synthetic methodology for the asymmetric syntheses of naturally occurring or pharmaceutically interesting hydroxylated pyrrolidines, 2-pyrrolidinones, b-hydroxy-g-amino acids, and their higher homologous, as well as tetramic acid and tetramate derivatives via new chiral non-racemic synthons A ~ C; and the enantio-divergent syntheses of both enantiomers of the marine alkaloid haliclorensin and isohaliclorensin, a constituent of cytotoxic marine alkaloid halitulin. |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://dspace.xmu.edu.cn/handle/2288/64449] ![]() |
专题 | 化学化工-已发表论文 |
推荐引用方式 GB/T 7714 | Huang, PQ,Huang PQ. ORGN 67-Flexible approaches for the asymmetric synthesis of bioactive alkaloids[J],2008. |
APA | Huang, PQ,&黄培强.(2008).ORGN 67-Flexible approaches for the asymmetric synthesis of bioactive alkaloids.. |
MLA | Huang, PQ,et al."ORGN 67-Flexible approaches for the asymmetric synthesis of bioactive alkaloids".(2008). |
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