A versatile approach for the asymmetric synthesis of 3-alkyl-2,3-dihydro-1H-isoindolin-1-ones

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	A versatile approach for the asymmetric synthesis of 3-alkyl-2,3-dihydro-1H-isoindolin-1-ones
	Chen, MD ; Zhou, X ; He, MZ ; Ruan, YP ; Huang, PQ ; Huang PQ(黄培强)
刊名	http://dx.doi.org/10.1016/j.tet.2003.11.092
	2004-02-09
关键词	DIASTEREOSELECTIVE STRECKER SYNTHESIS DIELS-ALDER REACTIONS ENANTIOSELECTIVE SYNTHESIS STEREOSELECTIVE-SYNTHESIS ALPHA-PHENYLGLYCINOL CONVENIENT SYNTHESIS CHIRAL AUXILIARIES GRIGNARD ADDITIONS OXIDATIVE REMOVAL REAGENTS
英文摘要	Based on the use of (R)-p-benzyloxyphenylglycinol (10) as a new oxidatively cleavable chiral auxiliary, a flexible approach to (R)-3-alkyl-2,3-dihydro-1H-isoindolin-1-ones via a diastereoselective reductive-alkylation is developed. The oxidative cleavage of the chiral auxiliary by CAN under mild conditions ensured the access to (R)-3-alkyl-2,3-dihydro-1H-isoindolin-1-ones with ee at least 92%. (C) 2003 Elsevier Ltd. All rights reserved.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/64413]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Chen, MD,Zhou, X,He, MZ,et al. A versatile approach for the asymmetric synthesis of 3-alkyl-2,3-dihydro-1H-isoindolin-1-ones[J]. http://dx.doi.org/10.1016/j.tet.2003.11.092,2004.
APA	Chen, MD,Zhou, X,He, MZ,Ruan, YP,Huang, PQ,&黄培强.(2004).A versatile approach for the asymmetric synthesis of 3-alkyl-2,3-dihydro-1H-isoindolin-1-ones.http://dx.doi.org/10.1016/j.tet.2003.11.092.
MLA	Chen, MD,et al."A versatile approach for the asymmetric synthesis of 3-alkyl-2,3-dihydro-1H-isoindolin-1-ones".http://dx.doi.org/10.1016/j.tet.2003.11.092 (2004).