A general approach to (5S,6R)-6-alkyl-5-benzyloxy-2-piperidinones: Application to the asymmetric syntheses of neurokinin substance P receptor antagonist (-)-L-733,061 and (-)-deoxocassine

CORC > 厦门大学 > 化学化工－已发表论文

	A general approach to (5S,6R)-6-alkyl-5-benzyloxy-2-piperidinones: Application to the asymmetric syntheses of neurokinin substance P receptor antagonist (-)-L-733,061 and (-)-deoxocassine
	Liu, LX ; Ruan, YP ; Guo, ZQ ; Huang, PQ ; Huang PQ(黄培强)
刊名	http://dx.doi.org/10.1021/jo049166z
	2004-09-03
关键词	N-ACYLIMINIUM IONS STEREOSELECTIVE-SYNTHESIS PIPERIDINE ALKALOIDS CYCLIC AMINES ACID DERIVATIVES (2S,3S)-3-HYDROXY-2-PHENYLPIPERIDINE DIASTEREOISOMERS (-)-ANISOMYCIN DIASTEREOMERS
英文摘要	A general approach to (5S,6R)-6-alkyl-5-benzyloxy-2-piperidinones based on the regio- and diastereoselective reductive alkylation of (S)-3-benzyloxyglutarimide 7 is described. This method opens an entrance to chiral nonracemic substituted 3-piperidinols. The versatility of the method is illustrated by the asymmetric syntheses of neurokinin substance P receptor antagonist L-733,061 (ent-1), (-)-deoxocassine (4), and an inhibitor of HIV proteases (5a).
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/64398]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Liu, LX,Ruan, YP,Guo, ZQ,et al. A general approach to (5S,6R)-6-alkyl-5-benzyloxy-2-piperidinones: Application to the asymmetric syntheses of neurokinin substance P receptor antagonist (-)-L-733,061 and (-)-deoxocassine[J]. http://dx.doi.org/10.1021/jo049166z,2004.
APA	Liu, LX,Ruan, YP,Guo, ZQ,Huang, PQ,&黄培强.(2004).A general approach to (5S,6R)-6-alkyl-5-benzyloxy-2-piperidinones: Application to the asymmetric syntheses of neurokinin substance P receptor antagonist (-)-L-733,061 and (-)-deoxocassine.http://dx.doi.org/10.1021/jo049166z.
MLA	Liu, LX,et al."A general approach to (5S,6R)-6-alkyl-5-benzyloxy-2-piperidinones: Application to the asymmetric syntheses of neurokinin substance P receptor antagonist (-)-L-733,061 and (-)-deoxocassine".http://dx.doi.org/10.1021/jo049166z (2004).