Near-infrared fluorescent nanoprobes for cancer molecular imaging: status and challenges

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	Near-infrared fluorescent nanoprobes for cancer molecular imaging: status and challenges
	He, XX ; Gao, JH ; Gambhir, SS ; Cheng, Z ; Gao JH(高锦豪)
刊名	http://dx.doi.org/10.1016/j.molmed.2010.08.006
	2010-12
关键词	SEMICONDUCTOR QUANTUM DOTS CELL-PENETRATING PEPTIDES RESONANCE ENERGY-TRANSFER MULTIFUNCTIONAL MAGNETIC NANOPARTICLES PROTEIN-PROTEIN INTERACTIONS WALLED CARBON NANOTUBES GROWTH-FACTOR RECEPTOR IN-VIVO LIVING SUBJECTS TUMOR VASCULATURE
英文摘要	National Cancer Institute/National Institutes of Health (NCI/NIH) [R21 CA121842]; NCI In vivo Cellular and Molecular Imaging Centers (ICMIC) [P50]; NCI Center for Cancer Nanotechnology Excellence [U54 CA119367]; Near-infrared fluorescence (NIRF) imaging promises to improve cancer imaging and management; advances in nanomaterials allow scientists to combine new nanoparticles with NIRF imaging techniques, thereby fulfilling this promise. Here, we present a synopsis of current developments in NIRF nanoprobes, their use in imaging small living subjects, their pharmacokinetics and toxicity, and finally their integration into multimodal imaging strategies. We also discuss challenges impeding the clinical translation of NIRF nanoprobes for molecular imaging of cancer. Whereas utilization of most NIRF nanoprobes remains at a proof-of-principle stage, optimizing the impact of nanomedicine in cancer patient diagnosis and management will probably be realized through persistent interdisciplinary amalgamation of diverse research fields.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/64320]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	He, XX,Gao, JH,Gambhir, SS,et al. Near-infrared fluorescent nanoprobes for cancer molecular imaging: status and challenges[J]. http://dx.doi.org/10.1016/j.molmed.2010.08.006,2010.
APA	He, XX,Gao, JH,Gambhir, SS,Cheng, Z,&高锦豪.(2010).Near-infrared fluorescent nanoprobes for cancer molecular imaging: status and challenges.http://dx.doi.org/10.1016/j.molmed.2010.08.006.
MLA	He, XX,et al."Near-infrared fluorescent nanoprobes for cancer molecular imaging: status and challenges".http://dx.doi.org/10.1016/j.molmed.2010.08.006 (2010).