Development of acetylcholinesterase biosensor based on CdTe quantum dots/gold nanoparticles modified chitosan microspheres interface

CORC > 厦门大学 > 化学化工－已发表论文

	Development of acetylcholinesterase biosensor based on CdTe quantum dots/gold nanoparticles modified chitosan microspheres interface
	Du, D. ; Chen, S. Z. ; Song, D. D. ; Li, H. B. ; Chen, X. ; Chen X(陈曦)
刊名	http://dx.doi.org/10.1016/j.bios.2008.05.005
	2008-11-15
关键词	GOLD NANOPARTICLES GLUCOSE-OXIDASE DIRECT ELECTROCHEMISTRY MODIFIED ELECTRODE IMMOBILIZATION FILMS DOTS GEL DEPOSITION CELLS
英文摘要	National Natural Science Foundation of China [20705010, 20775064, 20735002, 20772038]; Research Fund for the Doctoral Program of Higher Education [20070511015]; Program for Distinguish Young Scientist of Hubei Province [2007ABB017]; Program for Chenguang; In this paper, a novel acetylcholinesterase (ACNE) biosensor was constructed by modifying glassy carbon electrode with CdTe quantum dots (QDs) and excellent conductive gold nanoparticles (GNPs) though chitosan microspheres to immobilize ACNE. Since GNPs have shown widespread use particularly for constructing electrochemical biosensors through their high electron-transfer ability, the combined ACNE exhibited high affinity to its substrate and thus a sensitive, fast and cheap method for determination of monocrotophos. The combination of CdTe QDs and GNPs promoted electron transfer and catalyzed the electro-oxidation of thiocholine, thus amplifying the detection sensitivity. This novel biosensing platform based on CdTe QDs-GNPs composite responded even more sensitively than that on CdTe QDs or GNPs alone because of the presence of synergistic effects in CdTe-GNPs film. The inhibition of monocrotophos was proportional to its concentration in two ranges, from 1 to 1000 ng mL(-1) and from 2 to 15 mu g mL(-1). with a detection limit of 0.3 ng mL(-1). The proposed biosensor showed good precision and reproducibility, acceptable stability and accuracy in garlic samples analysis. (C) 2008 Elsevier B.V. All rights reserved.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/64192]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Du, D.,Chen, S. Z.,Song, D. D.,et al. Development of acetylcholinesterase biosensor based on CdTe quantum dots/gold nanoparticles modified chitosan microspheres interface[J]. http://dx.doi.org/10.1016/j.bios.2008.05.005,2008.
APA	Du, D.,Chen, S. Z.,Song, D. D.,Li, H. B.,Chen, X.,&陈曦.(2008).Development of acetylcholinesterase biosensor based on CdTe quantum dots/gold nanoparticles modified chitosan microspheres interface.http://dx.doi.org/10.1016/j.bios.2008.05.005.
MLA	Du, D.,et al."Development of acetylcholinesterase biosensor based on CdTe quantum dots/gold nanoparticles modified chitosan microspheres interface".http://dx.doi.org/10.1016/j.bios.2008.05.005 (2008).