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	Studies on the biotransformation of 16-O-demethyldeoxyaconitine of the metabolite of aconitine in human intestinal bacteria
	Zhao, Y. F. ; Song, F. R. ; Yue, H. ; Guo, X. H. ; Li, H. L. ; Liu, Z. Q. ; Liu, S. Y. ; Zhao YF(赵玉芬)
	2007
关键词	16-O-demethyldeoxyaconitine human intestinal bacteria biotransformation electrospray ionization mass spectrometry
英文摘要	To study the biotransformation of 16-O-demethyldeoxyaconitine in human intestine, aconitine was incubated with human intestinal bacteria in vitro. The metabolites of 16-O-demethyldeoxyaconitine were directly investigated using electrospray ionization tandem mass spectrometry (ESI-MS"). Aconitum alkaloids formed protonated molecule [M + H](+) in the positive ion mode. 16-O-demethyldeoxyaconitine can be transformed by human intestinal bacteria. It was converted into more than 10 kinds of new metabolites such as mono-ester alkaloids, diester alkaloids and lipo-alkaloids by deacetylation, debenzoyltion, dehydroxylation, demethylation and esterification. Diester alkaloids are very toxical. However, the toxicity of mono-ester alkaloids and lipo-alkaloids are less than that of diester alkaloids. When 16-O-demethyldeoxyaconitine was transfor med into mono-ester alkaloids and lipo-alkaloids by human intestinal bacteria, the toxicity degraded.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/63556]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Zhao, Y. F.,Song, F. R.,Yue, H.,et al. Studies on the biotransformation of 16-O-demethyldeoxyaconitine of the metabolite of aconitine in human intestinal bacteria[J],2007.
APA	Zhao, Y. F..,Song, F. R..,Yue, H..,Guo, X. H..,Li, H. L..,...&赵玉芬.(2007).Studies on the biotransformation of 16-O-demethyldeoxyaconitine of the metabolite of aconitine in human intestinal bacteria..
MLA	Zhao, Y. F.,et al."Studies on the biotransformation of 16-O-demethyldeoxyaconitine of the metabolite of aconitine in human intestinal bacteria".(2007).

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