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	Sequestration of Copper from beta-Amyloid Promotes Selective Lysis by Cyclen-Hybrid Cleavage Agents
	Wu, W. H. ; Lei, P. ; Liu, Q. ; Hu, J. ; Gunn, A. P. ; Chen, M. S. ; Rui, Y. F. ; Su, X. Y. ; Xie, Z. P. ; Zhao, Y. F. ; Bush, A. I. ; Li, Y. M. ; Zhao YF(赵玉芬)
	2008
关键词	ALZHEIMER A-BETA TRANSGENIC MICE HIPPOCAMPAL-NEURONS HYDROGEN-PEROXIDE DISEASE PEPTIDE BINDING OLIGOMERS CU(II) ZINC
英文摘要	Decelerated degradation of beta-amyloid (A beta) and its interaction with synaptic copper may be pathogenic in Alzheimer disease. Recently, Co(III)-cyclen tagged to an aromatic recognition motif was shown to degrade A beta in vitro. Here, we report that apocyclen attached to selective A beta recognition motifs (KLVFF or curcumin) can capture copper bound to A beta and use the Cu(II) in place of Co(III) to become proteolytically active. The resultant complexes interfere with A beta aggregation, degrade A beta into fragments, preventing H2O2 formation and toxicity in neuronal cell culture. Because A beta binds Cu in amyloid plaques, apocyclen-tagged targeting molecules may be a promising approach to the selective degradation of A beta in Alzheimer disease. The principle of copper capture generalize to other amyloidoses where copper is implicated.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/63550]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Wu, W. H.,Lei, P.,Liu, Q.,et al. Sequestration of Copper from beta-Amyloid Promotes Selective Lysis by Cyclen-Hybrid Cleavage Agents[J],2008.
APA	Wu, W. H..,Lei, P..,Liu, Q..,Hu, J..,Gunn, A. P..,...&赵玉芬.(2008).Sequestration of Copper from beta-Amyloid Promotes Selective Lysis by Cyclen-Hybrid Cleavage Agents..
MLA	Wu, W. H.,et al."Sequestration of Copper from beta-Amyloid Promotes Selective Lysis by Cyclen-Hybrid Cleavage Agents".(2008).

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