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	Insulin is a kinetic but not a thermodynamic inhibitor of amylin aggregation
	Cui, W. ; Ma, J. W. ; Lei, P. ; Wu, W. H. ; Yu, Y. P. ; Xiang, Y. ; Tong, A. J. ; Zhao, Y. F. ; Li, Y. M. ; Zhao YF(赵玉芬)
	2009
关键词	aggregation amylin inhibition insulin type 2 diabetes
英文摘要	One of the most important pathological features of type 2 diabetes is the formation of islet amyloid, of which the major component is amylin peptide. However, the presence of a natural inhibitor such as insulin may keep amylin stable and physiologically functional in healthy individuals. Some previous studies demonstrated that insulin was a potent inhibitor of amylin fibril formation in vitro, but others obtained contradictory results. Hence, it is necessary to elucidate the effects of insulin on amylin aggregation. Here we report that insulin is a kinetic inhibitor of amylin aggregation, only keeping its inhibitory effect for a limited time period. Actually, insulin promotes amylin aggregation after long-term incubation. Furthermore, we found that this promotional effect could be attributed to the copolymerization of insulin and amylin. We also found that insulin copolymerized with amylin monomer or oligomer rather than preformed amylin fibrils. These results suggest that the interaction between insulin and amylin may contribute not only to the inhibition of amylin aggregation but also to the coaggregation of both peptides in type 2 diabetes.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/63539]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Cui, W.,Ma, J. W.,Lei, P.,et al. Insulin is a kinetic but not a thermodynamic inhibitor of amylin aggregation[J],2009.
APA	Cui, W..,Ma, J. W..,Lei, P..,Wu, W. H..,Yu, Y. P..,...&赵玉芬.(2009).Insulin is a kinetic but not a thermodynamic inhibitor of amylin aggregation..
MLA	Cui, W.,et al."Insulin is a kinetic but not a thermodynamic inhibitor of amylin aggregation".(2009).

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