Studies on the synthesis of 2-acyl-1H-indenes via one-pot palladium-catalysed tandem Heck-aldol reaction

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	Studies on the synthesis of 2-acyl-1H-indenes via one-pot palladium-catalysed tandem Heck-aldol reaction
	Tu, S. ; Sha, Y. ; Xu, L. H. ; Xiao, Z. Y. ; Ye, L. Y. ; Fang, J. ; Sha Y(沙勇)
刊名	http://dx.doi.org/10.3184/030823410X12731659649772
	2010-05
关键词	CARBONYL-COMPOUNDS DERIVATIVES ARYLATION ALCOHOLS
英文摘要	High-Tech Research and Development Program of China [2008AA05Z107]; National Nature Science Foundation of China [20876129]; 2-Acyl-1H-indenes were synthesised efficiently by the reaction of o-halogenatedbenzaldehydes (or aryl ketones) with prop-2-en-1-ols via one-pot palladium-catalysed tandem Heck-aldol reaction in moderate to good yields. The optimal reaction conditions have been investigated and it was found that sodium acetate was the most effective base and in addition tetrabutylammonium chloride and LiCl was crucial for this process. Moreover, it was found that o-halogenatedbenzaldehydes react with various substituted prop-2-en-1-ols smoothly to produce the title compounds while 2-bromoacetophenone only reacted with 2-propen-1-ol to give the desired product.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/62670]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Tu, S.,Sha, Y.,Xu, L. H.,et al. Studies on the synthesis of 2-acyl-1H-indenes via one-pot palladium-catalysed tandem Heck-aldol reaction[J]. http://dx.doi.org/10.3184/030823410X12731659649772,2010.
APA	Tu, S..,Sha, Y..,Xu, L. H..,Xiao, Z. Y..,Ye, L. Y..,...&沙勇.(2010).Studies on the synthesis of 2-acyl-1H-indenes via one-pot palladium-catalysed tandem Heck-aldol reaction.http://dx.doi.org/10.3184/030823410X12731659649772.
MLA	Tu, S.,et al."Studies on the synthesis of 2-acyl-1H-indenes via one-pot palladium-catalysed tandem Heck-aldol reaction".http://dx.doi.org/10.3184/030823410X12731659649772 (2010).