Preparation and physical properties of a novel biocompatible porcine corneal acellularized matrix

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	Preparation and physical properties of a novel biocompatible porcine corneal acellularized matrix
	Shao, Yi ; Quyang, Luowa ; Zhou, Yueping ; Tang, Jing ; Tan, Yuehui ; Liu, Qiuping ; Lin, Zhirong ; Yin, Tingting ; Qiu, Fangfang ; Liu, Zuguo ; Tang J(汤儆)
刊名	http://dx.doi.org/10.1007/s11626-010-9328-9
	2010-07
关键词	CROSS-LINKED COLLAGEN XENOTRANSPLANTATION EQUIVALENT SCAFFOLD PROGRESS BABOONS STROMA RABBIT
英文摘要	National High Technology Research and Development Program of the Eleventh Five-Year Plan of China [2006AA02A131]; National Natural Science Fundation of China [30600697, 30572001, 30700926]; This study was to investigate the stability, physico-mechanical property and biocompatibility of porcine corneal acellularized matrix (PCAM) that was prepared using human sera treatment to decellularize corneas. The stability (the rate of biodegradation) and physico-mechanical property (water uptake, density, and porosity) of PCAM were not compromised, compared with porcine fresh cornea matrix (PFCM, p > 0.05). The contact and extract cytotoxicity tests with human corneal epithelial cells and human keratocytes showed that PCAM has a good biocompatibility ex vivo and no cytotoxic effect. These results present the ability to create safety scaffolds that function as cornea grafts and provide a novel experimental approach for the study of cornea tissue engineering using acellular porcine cornea.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/62669]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Shao, Yi,Quyang, Luowa,Zhou, Yueping,et al. Preparation and physical properties of a novel biocompatible porcine corneal acellularized matrix[J]. http://dx.doi.org/10.1007/s11626-010-9328-9,2010.
APA	Shao, Yi.,Quyang, Luowa.,Zhou, Yueping.,Tang, Jing.,Tan, Yuehui.,...&汤儆.(2010).Preparation and physical properties of a novel biocompatible porcine corneal acellularized matrix.http://dx.doi.org/10.1007/s11626-010-9328-9.
MLA	Shao, Yi,et al."Preparation and physical properties of a novel biocompatible porcine corneal acellularized matrix".http://dx.doi.org/10.1007/s11626-010-9328-9 (2010).