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	Nonlinear optical imaging of melanocytes in collagen matrix
	Yang CY(杨朝勇)
	2007
英文摘要	Nonlinear optical microscopy can achieve three-dimensional high-resolution images of tissue components with high sensitivity and specificity. We combine two-photon excited fluorescence (TPEF), four-wave mixing (FWM), and optically active sum-frequency generation (OA-SFG) for simultaneous imaging of unstained skin tissues. Intrinsic fluorophores in cancerous cells contribute to high-contrast TPEF images, whereas collagen fibers with large nonlinear susceptibility generate sizeable FWM signals. Our studies reveal different formation patterns in two clinically distinct skin tissue biopsies and show possible influence of collagen fibers by the growth of cancerous cells. Our result demonstrated that the simultaneous nonlinear imaging through TPEF, FWM and OA-SFG serves as a promising new approach for early diagnosis of skin cancer.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/62396]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Yang CY. Nonlinear optical imaging of melanocytes in collagen matrix[J],2007.
APA	杨朝勇.(2007).Nonlinear optical imaging of melanocytes in collagen matrix..
MLA	杨朝勇."Nonlinear optical imaging of melanocytes in collagen matrix".(2007).

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