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	Multifaceted cytoprotection by synthetic polyacetylenes inspired by the ginseng-derived natural product, panaxytriol
	Chou, Ting-Chao ; Dong, Huajin ; Zhang, Xiuguo ; Lei, Xiaoguang ; Hartung, John ; Zhang, Yandong ; Lee, Jun Hee ; Wilson, Rebecca M. ; Danishefsky, Samuel J. ; Zhang YD(张延东)
	2011
关键词	DRUG DISCOVERY ACTIVE COMPONENT PANAX-GINSENG RED-GINSENG NUDE-MICE FLUDELONE RESPONSES EXTRACT RATS
英文摘要	We describe herein the discovery of a series of panaxytriol (PXT)-derived polyacetylene small molecules with promising cytoprotective activity. In mouse xenograft models, we have demonstrated the capacity of our synthetic analogs to mitigate a range of cancer therapeutic agent-induced toxicities, including body weight loss, lethality, neurotoxicity, and hematotoxicity. Our PXT analogs have also been found to reduce radiation-induced body weight loss and lethality in mouse models. Moreover, several PXT analogs appear to exhibit moderate in vivo antiinflammatory activity as well as in vitro immunoenhancing capabilities. These compounds appear to derive their activity through induction of cancer preventive phase 2 enzymes. The studies described herein suggest that coadministration of a PXT-derived agent with cancer chemotherapeutics or radiation therapy may serve to mitigate a range of therapy-associated toxicities.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/61972]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Chou, Ting-Chao,Dong, Huajin,Zhang, Xiuguo,et al. Multifaceted cytoprotection by synthetic polyacetylenes inspired by the ginseng-derived natural product, panaxytriol[J],2011.
APA	Chou, Ting-Chao.,Dong, Huajin.,Zhang, Xiuguo.,Lei, Xiaoguang.,Hartung, John.,...&张延东.(2011).Multifaceted cytoprotection by synthetic polyacetylenes inspired by the ginseng-derived natural product, panaxytriol..
MLA	Chou, Ting-Chao,et al."Multifaceted cytoprotection by synthetic polyacetylenes inspired by the ginseng-derived natural product, panaxytriol".(2011).

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