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	Immobilization of Quantum Dots in Multiple Responsive Microgels for Biomedical Applications
	Wu, W. T. ; Zhou, T. ; Aiello, M. ; Zhou, S. Q. ; Wu WT(吴伟泰)
	2010
关键词	Optical glucose sensing quantum dots smart hybrid microgels
英文摘要	A novel type of smart hybrid materials based on the in situ immobilization of quantum dots (QDs) on a responsive microgel template was prepared and investigated. Firstly, a temperature and pH dual responsive hybrid microgel was developed through the in-situ immobilization of CdS QDs in the interior of a copolymer microgel of poly(N-isopropylacrylamide-acrylamide-acrylic acid) [p(NIPAM-AAm-AA)]. The amino groups of the pAAm segments in the microgels are designed to sequester the precursor Cd(2+) ions for in situ formation of CdS QDs in the interior of the microgels and stabilize the CdS QDs embedded in the microgels. We demonstrated that the carboxyl groups on the p(NIPAM-AAm-AA)-CdS hybrid microgels can be used for further coupling with 3-aminophenyl boronic acid for optical glucose sensing. The glucose concentration change can induce a reversible swelling/shrinkage of the hybrid microgels, which can further modify the physicochemical environment of the QDs immobilized inside the microgels, resulting in a reversible quenching/antiquenching in photoluminescence (PL). The method is extendable to other QDs with different emission wavelengths and other targeting ligands, thus it is possible to develop multifunctional hybrid micro-/nano-gels for additional important biomedical applications.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/61462]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Wu, W. T.,Zhou, T.,Aiello, M.,et al. Immobilization of Quantum Dots in Multiple Responsive Microgels for Biomedical Applications[J],2010.
APA	Wu, W. T.,Zhou, T.,Aiello, M.,Zhou, S. Q.,&吴伟泰.(2010).Immobilization of Quantum Dots in Multiple Responsive Microgels for Biomedical Applications..
MLA	Wu, W. T.,et al."Immobilization of Quantum Dots in Multiple Responsive Microgels for Biomedical Applications".(2010).

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