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	A Multifuntional Nanoplatform Based on Responsive Fluorescent Plasmonic ZnO-Au@PEG Hybrid Nanogels
	Wu, W. T. ; Shen, J. ; Banerjee, P. ; Zhou, S. Q. ; Wu WT(吴伟泰)
	2011
关键词	QUANTUM DOTS GOLD NANOPARTICLES DRUG-DELIVERY IN-VIVO MULTIFUNCTIONAL NANOPARTICLES CDTE NANOCRYSTALS CANCER-THERAPY SEMICONDUCTOR TEMPERATURE MICROGELS
英文摘要	Under a rational design, combining multiple constituents into a single nano-object will not only bridge the unique properties of individual materials to leverage research both fundamentally and practically, but will also improve conventional sensing, imaging, and therapeutic efficacies. Such a nano-object (<100 nm) can be constructed by covalently bonding ZnO quantum dots (QDs) to nonlinear poly(ethylene glycol)-based nanogel network chains, followed by appropriate growth of metallic Au. With the polymer gel network serving as a three-dimensional scaffold, the fluorescence of ZnO QDs can be well protected, while metal Au still retains its surface plasmon resonance property. The ZnO QDs covalently bonded to the thermo-responsive gel network chains can sensitively respond to temperature change of the surrounding fluids over the physiologically important range of 37-42 degrees C, converting the disruptions in homeostasis of local temperature into stable, robust and high-resolution fluorescent signals. The thermoresponsive hybrid nanogels can not only enter into and light up B16F10 cells, but also regulate the release of a model anticancer drug, temozolomide, in response to either local environmental temperature change or external near-infrared light-induced localized hyperthermia from metal Au. The combined chemo-photothermal therapy can significantly improve the therapeutic efficacy due to a synergistic effect.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/61461]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Wu, W. T.,Shen, J.,Banerjee, P.,et al. A Multifuntional Nanoplatform Based on Responsive Fluorescent Plasmonic ZnO-Au@PEG Hybrid Nanogels[J],2011.
APA	Wu, W. T.,Shen, J.,Banerjee, P.,Zhou, S. Q.,&吴伟泰.(2011).A Multifuntional Nanoplatform Based on Responsive Fluorescent Plasmonic ZnO-Au@PEG Hybrid Nanogels..
MLA	Wu, W. T.,et al."A Multifuntional Nanoplatform Based on Responsive Fluorescent Plasmonic ZnO-Au@PEG Hybrid Nanogels".(2011).

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