Combination of human plasminogen kringle 5 with ionizing radiation significantly enhances the efficacy of antitumor effect

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	Combination of human plasminogen kringle 5 with ionizing radiation significantly enhances the efficacy of antitumor effect
	Jin, Guang-Hui ; Ma, Ding-Yuan ; Wu, Ning ; Marikar, Faiz M. M. T. ; Jin, Shun-Zi ; Jiang, Wei-Wei ; Liu, Yan ; Hua, Zi-Chun ; Liu Y(刘艳)
刊名	http://dx.doi.org/10.1002/ijc.22708
	2007-12-01
关键词	ENDOTHELIAL GROWTH-FACTOR UP-REGULATION LUNG-CANCER THERAPY CELLS ANGIOGENESIS ANGIOSTATIN EXPRESSION RADIOTHERAPY INHIBITION
英文摘要	Antiangiogenic therapy could destroy tumor vasculature and inhibit tumor growth. It might inhibit tumor growth significantly when used as a single treatment modality and its therapeutic benefit may even be greater when used in combination with established treatment modalities such as radiation therapy (RT). In the present report, we investigated the effect of recombinant human plasminogen kringle 5 domain (rhK5) in combination with ionizing radiation on angiogenesis, tumor growth and survival in a murine Lewis lung carcinoma (LLC) tumor model. Combined treatment using rhK5 and radiotherapy displayed obvious suppressive effect on LLC tumor growth as compared with single treatment with either modality (p < 0.05), and resulted in a more additive effect on tumor growth delay in this model. In addition, combined treatment significantly enhanced the survival of mice and no toxic effect, such as weight loss, was observed. The significant antitumor effect of rhK5 plus radiation was associated with a direct suppression effect on early neoangiogenesis and tumor cell apoptosis. Furthermore, the expression of VEGF and HIF-1 alpha in tumor tissue correlated well with decreased vessel density. The results suggest that rhK5 significantly enhances the antitumor activity of RT and could be a potent adjuvant therapeutic approach to improve the efficacy of radiotherapy for lung cancer. (C) 2007 Wiley-Liss, Inc.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/61309]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Jin, Guang-Hui,Ma, Ding-Yuan,Wu, Ning,et al. Combination of human plasminogen kringle 5 with ionizing radiation significantly enhances the efficacy of antitumor effect[J]. http://dx.doi.org/10.1002/ijc.22708,2007.
APA	Jin, Guang-Hui.,Ma, Ding-Yuan.,Wu, Ning.,Marikar, Faiz M. M. T..,Jin, Shun-Zi.,...&刘艳.(2007).Combination of human plasminogen kringle 5 with ionizing radiation significantly enhances the efficacy of antitumor effect.http://dx.doi.org/10.1002/ijc.22708.
MLA	Jin, Guang-Hui,et al."Combination of human plasminogen kringle 5 with ionizing radiation significantly enhances the efficacy of antitumor effect".http://dx.doi.org/10.1002/ijc.22708 (2007).