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	Investigation of DNA orientation on gold by EC-STM
	Zhang, ZL ; Pang, DW ; Zhang, RY ; Yan, JW ; Yan JW(颜佳伟) ; Mao, BW ; Mao BW(毛秉伟) ; Qi, YP
	2001-12-13
英文摘要	The immobilization of thiol-derivatized DNA on a Au (111) single crystal surface by self-assembly has been investigated by electrochemical scanning tunneling microscopy (EC-STM). Continuous potential-dependent orientation changes of double-stranded oligodeoxynucleotides (ODN) have been observed in a certain potential range from 200 to 600 mV (versus SCE). It is suggested that the DNA duplexes stand straight on the gold surface at potentials negative of the potential of zero charge (pzc) and then lay down on the surface when the potential shifts positively. These results are in agreement with the expectation based on the Coulombic interaction consideration between negatively charged DNA helices and gold surface. As the applied potential shifts positively, the surface charge changes from negative to positive, that is, the Coulombic force between negatively charged DNA helices and gold surfaces changes from repulsion to attraction. However, for the single-stranded oligodeoxynucleotides, no distinct changes in the surface structure were observed with the applied potential.
语种	英语
出版者	AMER CHEMICAL SOC
内容类型	期刊论文
源URL	[http://dx.doi.org/doi: 10.1021/bc0155263]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Zhang, ZL,Pang, DW,Zhang, RY,et al. Investigation of DNA orientation on gold by EC-STM[J],2001.
APA	Zhang, ZL.,Pang, DW.,Zhang, RY.,Yan, JW.,颜佳伟.,...&Qi, YP.(2001).Investigation of DNA orientation on gold by EC-STM..
MLA	Zhang, ZL,et al."Investigation of DNA orientation on gold by EC-STM".(2001).

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