QQ客服 官方微博 反馈留言

	Analysis and leaching characteristics of mercury and arsenic in Chinese medicinal material
	Wu, XH ; Sun, DH ; Sun DH(孙道华) ; Zhuang, ZX ; Zhuang ZS(庄峙厦) ; Wang, XR ; Wang XR(王小如) ; Gong, HF ; Hong, JX ; Lee, FSC
	2001-10-31
关键词	arsenic mercury Chinese medicinal materials inductively coupled plasma mass spectrometry hydride generation atomic fluorescence spectrometry
英文摘要	The purpose of this study is to investigate the amounts and characteristics of heavy metals (As, Hg) leachable from several Chinese medicinal materials (CM1\4) under conditions simulating stomach and intestine digestion and absorption. Analysis by inductively coupled plasma mass spectrometry (ICP-MS) was compared with that by hydride generation atomic fluorescence spectrometry (HG-AFS). Focused microwave assisted extraction (MAE) and Soxhlet extraction were carried out to compare with the conventional sequential extraction method. The CMM studied included two mineral drugs: realgar and cinnabar, and two formulated drugs containing the two minerals. The leachable amounts of the target elements into artificial stomach fluid, artificial intestinal fluid, and artificial intestinal fluid in 0.5% trypsin were compared. The last solvent gave the greatest amounts of leachable As (0.41%) from realgar and Hg (1 x 10(-4)%) from cinnabar, but otherwise no significant effect on the leachable amounts was observed upon changing the following parameters: temperature (37-60degreesC), HC1 concentration (0.5-6 M), and CMM sample particle size (74 and 250 mum). The low leaching efficiencies observed confirmed the presence of As and Hg as insoluble species (sulfides)in these mineral drugs. Sequential extraction schemes were used to determine the species of mercury and arsenic in formulated drugs containing the minerals. Trace amounts of organic forms of arsenic (0.43%) and mercury (2.9 x 10(-4)%) were observed which could be the transformation products derived from the original cinnabar or realgar minerals in drug formulation. (C) 2002 Elsevier Science B.V.. All rights reserved.
语种	英语
出版者	ELSEVIER SCIENCE BV
内容类型	期刊论文
源URL	[http://dx.doi.org/10.1016/S0003-2670(01)01442-8]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Wu, XH,Sun, DH,Sun DH,et al. Analysis and leaching characteristics of mercury and arsenic in Chinese medicinal material[J],2001.
APA	Wu, XH.,Sun, DH.,孙道华.,Zhuang, ZX.,庄峙厦.,...&Lee, FSC.(2001).Analysis and leaching characteristics of mercury and arsenic in Chinese medicinal material..
MLA	Wu, XH,et al."Analysis and leaching characteristics of mercury and arsenic in Chinese medicinal material".(2001).

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。