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	Coenzyme Q(10) nanoparticles prepared by a supercritical fluid-based method
	Hu, Xiaohui ; Guo, Yanni（ Xiamen Zijin Min & Met Technol Co Ltd） ; Wang, Lei ; Hua, Dan ; Hong, Yanzhen ; Li, Jun ; Li J(李军)
	2011-01-21
关键词	Supercritical fluid Gas-saturated solution Nanoparticles Coenzyme Q(10)
英文摘要	A supercritical fluid-based method is proposed to produce coenzyme Q(10) (CoQ(10)) nanoparticles. First, CoQ(10)/polyethylene glycol 6000 composite particles are prepared by a modified PGSS (particles from gas-saturated solutions) process with controlling the flow rate of the gas-saturated solution. Then, CoQ(10) nanoparticles are obtained by dissolving the composite particles into water. The effect of experimental variables of the modified PGSS process, including pressure, temperature, flow rate of the gas-saturated solution, and mass fraction of CoQ(10), on the CoQ(10) particle size and particle size distribution was investigated. Results show that CoQ(10) slurry product with a median diameter of 190 nm and yield of 89.8% can be prepared at an optimum condition (operating pressure of 25 MPa, operating temperature of 80 degrees C, gas-saturated solution flow rate of 1.02 mL/min, CoQ(10) mass fraction of 40% and nozzle diameter of 100 mu m) via the supercritical fluid-based method. (C) 2011 Elsevier B.V. All rights reserved.; SRF for ROCS, SEM; NCET of Fujian Province; NSFC, China[20876127]
语种	英语
出版者	ELSEVIER SCIENCE BV
内容类型	期刊论文
源URL	[http://dx.doi.org/doi:10.1016/j.supflu.2011.01.007]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Hu, Xiaohui,Guo, Yanni,Wang, Lei,et al. Coenzyme Q(10) nanoparticles prepared by a supercritical fluid-based method[J],2011.
APA	Hu, Xiaohui.,Guo, Yanni.,Wang, Lei.,Hua, Dan.,Hong, Yanzhen.,...&李军.(2011).Coenzyme Q(10) nanoparticles prepared by a supercritical fluid-based method..
MLA	Hu, Xiaohui,et al."Coenzyme Q(10) nanoparticles prepared by a supercritical fluid-based method".(2011).

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