QQ客服 官方微博 反馈留言

	Enhanced performance of lipase-catalyzed kinetic resolution of secondary alcohols in monoether-functionalized ionic liquids
	Zhou, Hancheng ; Chen, Jin ; Ye, Linmin ; Lin, Haiqiang ; Yuan, Youzhu ; Yuan YZ(袁友珠)
	2011-02-19
关键词	Monoether-functionalized ionic liquid Lipase Deracemization Kinetic resolution Secondary alcohol
英文摘要	Several cationic monoether-functionalized ionic liquids (MEF-ILs) with different substituents were synthesized and used as media for kinetic resolution of secondary alcohols catalyzed by several lipases. The results indicate that Novozym 435 (an immobilized Candida antarctica Lipase B) had higher efficiency compared to other lipases in deracemization. The alkyl substituents at the 2- and 3-positions in the imidazolium ring of MEF-ILs were found to contribute to the increased enantioselectivity and enhancement of the reaction rate, respectively, while the higher stereo-hindrance of ether bonds decreased the activity. An enantioselectivity higher than 99% with 50% conversion of rac-1-phenylethanol was achieved using the catalyst system comprised of Novozym 435 and the MEF-IL 1-(3-ethoxypropyl)-2,3-dimethylimidazolium bis(trifluoromethylsulfonyl)imide. The catalytic system could be separated and reused without considerable activity loss. MEF-ILs can be a new class of enzyme-benign media suitable for lipase-catalyzed kinetic resolution of secondary alcohols. (C) 2011 Elsevier Ltd. All rights reserved.; National Natural Science Foundation of China[20873108, 20923004]; NFFTBS[J1030415]; National Basic Research Program of China[2011CBA00508]
语种	英语
出版者	ELSEVIER SCI LTD
内容类型	期刊论文
源URL	[http://dx.doi.org/doi:10.1016/j.biortech.2011.02.066]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Zhou, Hancheng,Chen, Jin,Ye, Linmin,et al. Enhanced performance of lipase-catalyzed kinetic resolution of secondary alcohols in monoether-functionalized ionic liquids[J],2011.
APA	Zhou, Hancheng,Chen, Jin,Ye, Linmin,Lin, Haiqiang,Yuan, Youzhu,&袁友珠.(2011).Enhanced performance of lipase-catalyzed kinetic resolution of secondary alcohols in monoether-functionalized ionic liquids..
MLA	Zhou, Hancheng,et al."Enhanced performance of lipase-catalyzed kinetic resolution of secondary alcohols in monoether-functionalized ionic liquids".(2011).

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。