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	Controlled Release of Berberine Hydrochloride from Alginate Microspheres Embedded Within Carboxymethyl Chitosan Hydrogels
	Zhu, Ai Mei ; Zhu AM(朱爱梅) ; Chen, Jian Hua ; Liu, Qing Lin ; Liu QL(刘庆林) ; Jiang, Yu Liang
	2010-12-10
关键词	alginate microsphere carboxymethyl chitosan hydrogel berberine hydrochloride controlled release
英文摘要	Berberine hydrochloride is a natural medicine with wide clinical application. In this article, berberine hydrochloride was entrapped into alginate microspheres via an emulsification/gelation method. The size distribution of the microspheres was determined by a laser particle sizer. Drug distribution within the microspheres was determined by confocal laser scanning microscopy. Those drug-loaded microspheres were further entrapped into carboxymethyl chitosan (CMC) hydrogel to form a new drug-delivery system (DDS). The surface morphology of the DDS was observed using metallographic microscopy and scanning electron microscopy (SEM). The compression strength of the DDSs with alginate microspheres was found significantly higher than that of the pure hydrogel. The drug-release performances of the DDS in phosphate buffer solution (PBS, pH 7.4), saline solution (pH 6.3), and hydrochloric acid solution (HAS, pH 1.2) were also studied. Decay of the DDS in PBS within 72-80 h results in a faster release; however, the steady release in saline solution could last for all the testing period without cleavage of the DDS. In HAS, because of the shrinkage of the DDS, release is fast in the first period and remains steady later. The DDS exhibits prospective in controlled steady release of drugs. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 120: 2374-2380, 2011; National Nature Science Foundation of China[20976145, 21076170, 21076174]; Nature Science Foundation of Fujian Province of China[2009J01040]; Doctoral Program of Higher Education[20090121110031]
语种	英语
出版者	WILEY-BLACKWELL
内容类型	期刊论文
源URL	[http://dx.doi.org/doi:10.1002/app.33433]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Zhu, Ai Mei,Zhu AM,Chen, Jian Hua,et al. Controlled Release of Berberine Hydrochloride from Alginate Microspheres Embedded Within Carboxymethyl Chitosan Hydrogels[J],2010.
APA	Zhu, Ai Mei,朱爱梅,Chen, Jian Hua,Liu, Qing Lin,刘庆林,&Jiang, Yu Liang.(2010).Controlled Release of Berberine Hydrochloride from Alginate Microspheres Embedded Within Carboxymethyl Chitosan Hydrogels..
MLA	Zhu, Ai Mei,et al."Controlled Release of Berberine Hydrochloride from Alginate Microspheres Embedded Within Carboxymethyl Chitosan Hydrogels".(2010).

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