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	Controllable DNA Condensation-Release Induced by Simple Azaheterocyclic-Based Metal Complexes
	Li, Chao（Beijing Univ Chem Technol, Dept Pharmaceut Engn） ; Tian, Hua（Beijing Univ Chem Technol, Dept Pharmaceut Engn） ; Duan, Shan（Beijing Univ Chem Technol, Dept Pharmaceut Engn） ; Liu, Xuena（Beijing Univ Chem Technol, Dept Pharmaceut Engn） ; Xu, Pengfei（Lanzhou Univ, State Key Lab Appl Organ Chem） ; Qiao, Renzhong（Lanzhou Univ, State Key Lab Appl Organ Chem） ; Zhao, Yufen ; Zhao YF(赵玉芬)
	2011-09-14
英文摘要	The condensation of DNA is essential for biological processes such as DNA transcription and replication, and its study receives additional impetus from an interest in gene therapy. Although many efficacious condensing agents have been discovered and investigated, little is known about the conversation of condensation-release under suitable conditions. A novel class of DNA condensing agents based on small azaheterocyclic metal-binding molecules has been discovered and described. Both linear and plasmid DNA can be condensed to nanoparticles by the title compounds with 50 degrees C incubation, especially in the presence of divalent metal ions. Importantly, this condensation may be released to original forms with little or no damage to the DNA under incubation at physiological temperatures. These changes in DNA morphology over time have been analyzed by gel electrophoresis, circular dichroism (CD), and atomic force microscopy (AFM). The present work might help to develop strategies for the design and synthesis of controllable condensing agents, which may also be applied to control gene expression and delivery.; National Nature Science Foundation of China[20732004, 20872010, 20972014, 21172016]
语种	英语
出版者	AMER CHEMICAL SOC
内容类型	期刊论文
源URL	[http://dx.doi.org/doi:10.1021/jp206199b]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Li, Chao,Tian, Hua,Duan, Shan,et al. Controllable DNA Condensation-Release Induced by Simple Azaheterocyclic-Based Metal Complexes[J],2011.
APA	Li, Chao.,Tian, Hua.,Duan, Shan.,Liu, Xuena.,Xu, Pengfei.,...&赵玉芬.(2011).Controllable DNA Condensation-Release Induced by Simple Azaheterocyclic-Based Metal Complexes..
MLA	Li, Chao,et al."Controllable DNA Condensation-Release Induced by Simple Azaheterocyclic-Based Metal Complexes".(2011).

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