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	Preparation, release-control and cell apoptosis of liver cancer in the tea polyphenol manganese loaded on a chitosan microparticles
	Huang, He-Ning ; Huang HN(黄河宁) ; Li, Cheng ; Li C(李程) ; Xie, Li-Sheng ; Xie LS(谢笠升) ; Huang, He-Qing ; Huang HQ(黄河清)
	2008
关键词	TPMn-chitosan microparticles characteristics of physical chemistry controlling-release cell of liver cancer apotosis
英文摘要	The chitosan as a wrapping material was selected to prepare a microparticles of tea polyphenol manganese-chitosan(TPMn). Fluorescence characteristics of TPMn-chitosan microparticles was revealed by fluorescence microscopy. Size and distribution orderliness of TPMn-chitosan microparticles was further approved by the scanning electron microscopy and the transmission electron microscopy, respectively. The envelopment ratio of TPMn-chitosan microparticles was calculated to be 68% by RE-HPLC approach, which is in accordance with the ratio request of release-controlled drug at the micron level of microparticles. The results of kinetic studies show that two chitosan microparticles loaded on both tea polyphenol (TP) and TPMn, respectively, have capacity for controlling-release TP for exceeding 40 h, but this rate in TP microparticles was somewhat quicker than that of TPMn microparticles. Even so, both miscroparticles have capacity for inducing cells of liver cancer apoptosis, but this apoptosis rate by TPMn-chitosan microparticles was somewhat higher than that by TP-chitosan microparticles. The experimental results prove that the TPMn-chitosan microparticles was propitious to release and control TPMn for enhancing the apoptosis rate of tumour cell induced. TPMn-chitosan microparticles would have a potential for developing a new injecting drug for antitumor.
语种	英语
出版者	HIGHER EDUCATION PRESS
内容类型	期刊论文
源URL	[http://dx.doi.org/doi:CNKI:SUN:GDXH.0.2008-08-023]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Huang, He-Ning,Huang HN,Li, Cheng,et al. Preparation, release-control and cell apoptosis of liver cancer in the tea polyphenol manganese loaded on a chitosan microparticles[J],2008.
APA	Huang, He-Ning.,黄河宁.,Li, Cheng.,李程.,Xie, Li-Sheng.,...&黄河清.(2008).Preparation, release-control and cell apoptosis of liver cancer in the tea polyphenol manganese loaded on a chitosan microparticles..
MLA	Huang, He-Ning,et al."Preparation, release-control and cell apoptosis of liver cancer in the tea polyphenol manganese loaded on a chitosan microparticles".(2008).

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