QQ客服 官方微博 反馈留言

	Effect of Tanshinone IIA on the Noncovalent Interaction Between Warfarin and Human Serum Albumin Studied by Electrospray Ionization Mass Spectrometry
	Liu, Jie ; Wang, Xiaoru ; Wang XR(王小如) ; Cai, Zongwei（Hong Kong Baptist Univ, Dept Chem） ; Lee, Frank S. C.（First Inst Oceanog SOA, Key Lab Analyt Technol Dev & Standardizat Chinese）
	2008-06
英文摘要	Enhanced anticoagulation and/or even bleeding are often observed when patients on long-term warfarin (WAR) therapy consumed Danshen, a well-known medicinal herb in traditional Chinese medicine (TCM). This study demonstrates that altered WAR metabolism, arising from its interaction with the active components in Danshen, played a significant role in this curative effect. Mass spectrometric techniques including ESI-ITMS (electrospray ionization ion-trap mass spectrometry) and ESI-TOF (time-of-flight)-MS have been developed for the study Of Such drug-herb interactions. The experimental approach involved a detailed analysis and comparison of WAR metabolites in vivo from blood or Urine of rats that had been orally administrated with WAR, either singly or together with the representative bioactive component of Danshen-lipid Soluble TIIA (Tanshinon IIA), and a study of the interaction Of human serum albumin (HSA), WAR, and water-soluble sodium tanshinone ITA sulfonate (STS) in vitro. Results demonstrate that TIIA accelerates the metabolic rate of WAR, whereas STS displaces WAR from the WAR-HSA complex, resulting in an increase of free WAR concentration in blood. It is Suggested that the elevated level and enhanced metabolism of WAR is responsible for the over-anticoagulation effect observed. (J Am Soc Mass Spectrom 2008, 19, 1568-1575) (C) 2008 Published by Elsevier Inc. on behalf of American Society for Mass Spectrometry; Qingdao Biomedical Research and Testing Center ; Laoshan Scientific Department [LS-05-KJZX-76]; Research Grant Council, University Grants Committee of Hong Kong [HKBU2014/05M]
语种	英语
出版者	ELSEVIER SCIENCE INC
内容类型	期刊论文
源URL	[http://dx.doi.org/doi:10.1016/j.jasms.2008.06.005]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Liu, Jie,Wang, Xiaoru,Wang XR,et al. Effect of Tanshinone IIA on the Noncovalent Interaction Between Warfarin and Human Serum Albumin Studied by Electrospray Ionization Mass Spectrometry[J],2008.
APA	Liu, Jie,Wang, Xiaoru,王小如,Cai, Zongwei,&Lee, Frank S. C..(2008).Effect of Tanshinone IIA on the Noncovalent Interaction Between Warfarin and Human Serum Albumin Studied by Electrospray Ionization Mass Spectrometry..
MLA	Liu, Jie,et al."Effect of Tanshinone IIA on the Noncovalent Interaction Between Warfarin and Human Serum Albumin Studied by Electrospray Ionization Mass Spectrometry".(2008).

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。